Department of Medicine, Division of Gastroenterology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Cancer Biomark. 2010;9(1-6):493-507. doi: 10.3233/CBM-2011-0169.
Gastric cancer is one of the most common neoplasias in the world and remains an important cause of cancer-related mortality. Vast resources have been invested in the study of the molecular events driving the development and progression of gastric tumors. Gastric cancer is known to result from an interaction between host and environmental factors. The present review will discuss the most how genetic and epigenetic changes contribute to gastric carcinogenesis and their potential for developing novel diagnostic and therapeutic tools.
胃癌是世界上最常见的肿瘤之一，仍然是癌症相关死亡的重要原因。大量资源投入到研究驱动胃肿瘤发生和发展的分子事件中。已知胃癌是由宿主和环境因素相互作用引起的。本文综述将讨论遗传和表观遗传变化如何促进胃癌的发生发展及其在开发新的诊断和治疗工具方面的潜力。
