Labor Dr. Glatthaar, Beim Braunland 1, D-88416 Ochsenhausen, Germany.
Phytomedicine. 2011 Dec 15;19(1):1-7. doi: 10.1016/j.phymed.2011.10.010. Epub 2011 Nov 22.
Sinupret(®), a herbal medicinal product made from Gentian root, Primula flower, Elder flower, Sorrel herb, and Verbena herb is frequently used in the treatment of acute and chronic rhinosinusitis and respiratory viral infections such as common cold. To date little is known about its potential antiviral activity. Therefore experiments have been performed to measure the antiviral activity of Sinupret(®) oral drops (hereinafter referred to as "oral drops") and Sinupret(®) dry extract (hereinafter referred to as "dry extract"), in vitro against a broad panel of both enveloped and non-enveloped human pathogenic RNA and DNA viruses known to cause infections of the upper respiratory tract: influenza A, Chile 1/83 (H1N1) virus (FluA), Porcine Influenza A/California/07/2009 (H1N1) virus (pFluA), parainfluenza type 3 virus (Para 3), respiratory syncytial virus, strain Long (RSV), human rhinovirus B subtype 14 (HRV 14), coxsackievirus subtype A9 (CA9), and adenovirus C subtype 5 (Adeno 5). Concentration-dependent antiviral activity (EC(50) between 13.8 and 124.8 μg/ml) of Sinupret(®) was observed against RNA as well as DNA viruses independent of a viral envelope. Remarkable antiviral activity was shown against Adeno 5, HRV 14 and RSV in which dry extract was significantly superior to oral drops. This could be ascertained with different assays as plaque-reduction assays in plaque forming units (PFU), the analyses of a cytopathogenic effect (CPE) and with enzyme immunoassays (ELISA) to determine the amount of newly synthesised virus. Our results demonstrate that Sinupret(®) shows a broad spectrum of antiviral activity in vitro against viruses commonly known to cause respiratory infections.
辛普乐（®）是一种草药药物，由龙胆根、报春花、接骨木花、酢浆草和马鞭草制成，常用于治疗急性和慢性鼻-鼻窦炎和呼吸道病毒感染，如普通感冒。迄今为止，人们对其潜在的抗病毒活性知之甚少。因此，进行了实验以测量辛普乐（®）口服滴剂（以下简称“口服滴剂”）和辛普乐（®）干提取物（以下简称“干提取物”）对包膜和非包膜人类致病 RNA 和 DNA 病毒的体外抗病毒活性，这些病毒已知会引起上呼吸道感染：甲型流感、智利 1/83（H1N1）病毒（FluA）、猪流感 A/加利福尼亚/07/2009（H1N1）病毒（pFluA）、副流感 3 型病毒（Para 3）、呼吸道合胞病毒、长株（RSV）、人鼻病毒 B 亚型 14（HRV 14）、柯萨奇病毒 A9 型（CA9）和腺病毒 C 亚型 5（Adeno 5）。辛普乐（®）对 RNA 和 DNA 病毒具有浓度依赖性的抗病毒活性（EC（50）为 13.8 至 124.8μg/ml），与病毒包膜无关。对 Adeno 5、HRV 14 和 RSV 显示出显著的抗病毒活性，其中干提取物明显优于口服滴剂。这可以通过不同的测定法来确定，例如在形成单位（PFU）中进行噬菌斑减少测定法、分析细胞病变效应（CPE）以及使用酶免疫测定法（ELISA）来确定新合成病毒的量。我们的结果表明，辛普乐（®）在体外对常见引起呼吸道感染的病毒具有广谱抗病毒活性。
