Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland.
Molecules. 2011 Nov 23;16(11):9755-63. doi: 10.3390/molecules16119755.
A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, (1)H-NMR, and (13)C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
一系列可聚合的季铵盐化合物被合成，目的是将它们用作甲基丙烯酸酯牙科复合材料中的固定抗菌剂，并通过 FT-IR、（1）H-NMR 和（13）C-NMR 分析对其结构进行了表征。通过最低抑菌浓度试验评估了它们对口腔细菌变形链球菌的体外抗菌活性，结果表明 2-二甲基-2-十六烷基-1-甲基丙烯酰氧乙基碘化铵（C16）对 S. mutans 的抗菌活性最高，而 2-二甲基-2-戊基-1-甲基丙烯酰氧乙基碘化铵（C5）和 2-二甲基-2-辛基-1-甲基丙烯酰氧乙基碘化铵（C8）则没有显示任何抑制作用。
