Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity.
作者信息
Oka M, Kamei H, Hamagishi Y, Tomita K, Miyaki T, Konishi M, Oki T
机构信息
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
出版信息
J Antibiot (Tokyo). 1990 Aug;43(8):967-76. doi: 10.7164/antibiotics.43.967.
PMID:2211364
Abstract
A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A1, A2, B1, B2, C1 and C2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.
摘要
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