喹诺利霉素A1、A2和B1，新型60元大环内酯类抗生素。I. 分类学、发酵、分离、物理化学性质及生物活性。
Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
作者信息
Hayakawa Y, Matsuoka M, Shin-ya K, Seto H
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1993 Oct;46(10):1557-62. doi: 10.7164/antibiotics.46.1557.
PMID:8244883
Abstract
Three novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A1 inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B1 was similarly cytotoxic, while quinolidomicin A2 was inactive against these tumor cells.
摘要
从微小单孢菌属菌株JY16的发酵液中分离出三种新型大环内酯类抗生素，喹诺利霉素A1、A2和B1。喹诺利霉素A1抑制包括多药耐药细胞在内的多种肿瘤细胞的生长。喹诺利霉素B1同样具有细胞毒性，而喹诺利霉素A2对这些肿瘤细胞无活性。
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