来自链霉菌215种的一种抗生素（瓦苏霉素）的纯化、表征及抗菌特性

Purification, characterization and antimicrobial properties of an antibiotic (wassumycin) from Streptomyces species 215.

作者信息

Singh S, Gurusiddaiah S, Sunkara P S, Whalen J W

机构信息

Bioanalytical Center, Washington State University, Pullman 99164.

出版信息

Microbios. 1991;66(266):7-20.

PMID:1865832

Abstract

A yellow amorphous compound, wassumycin, was isolated from an unidentified strain of Streptomyces. Wassumycin inhibited the growth of several species of human and animal pathogenic bacteria especially Clostridia. Wassumycin also inhibited the growth of HeLa cells, and showed good antitumour activity against experimental mouse tumours such as L1210, P388 leukaemias, and B16 melanoma. On the basis of the chemical and antimicrobial properties, the antibiotic appeared similar to the chromomycins and olivomycins, but its ultraviolet, infrared, and proton magnetic resonance spectra differed from theirs significantly.

摘要

一种黄色无定形化合物——瓦苏霉素，是从一株未鉴定的链霉菌中分离出来的。瓦苏霉素能抑制多种人类和动物病原菌的生长，尤其是梭菌属细菌。瓦苏霉素还能抑制海拉细胞的生长，并对实验性小鼠肿瘤如L1210、P388白血病和B16黑色素瘤显示出良好的抗肿瘤活性。根据其化学和抗菌特性，这种抗生素似乎与色霉素和橄榄霉素相似，但其紫外、红外和质子磁共振光谱与它们有显著差异。