National Institute of Laser Enhanced Science, Cairo, Egypt.
Int J Nanomedicine. 2011;6:2155-65. doi: 10.2147/IJN.S23952. Epub 2011 Sep 28.
The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency.
Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice.
In mice treated with gold nanospheres, tumors continued to grow but at a slow rate. In contrast, more than 50% of the tumors treated with gold-coated magnetic nanocomposites completely disappeared.
This simple and noninvasive method shows great promise as a technique for selective magnetic photothermal treatment.
目前的射频消融技术需要进行有创的针置放。另一方面，大多数常见的光热治疗方法受到靶向准确性不足的限制。金和磁性纳米粒子通过与激光和射频的非侵入性相互作用，具有在细胞水平上选择性加热肿瘤组织的潜力。
使用金纳米球和金包覆的磁性纳米复合材料诱导热疗来治疗植入雌性小鼠的皮下艾氏腹水癌。
用金纳米球治疗的小鼠肿瘤继续生长，但生长速度较慢。相比之下，用金包覆的磁性纳米复合材料治疗的肿瘤中，超过 50%的肿瘤完全消失。
这种简单、非侵入性的方法为选择性磁光热治疗技术提供了很大的希望。
