Zhai Haiyan, Ju Jingfang
Translational Research Laboratory, Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY, USA.
Front Genet. 2011 Nov 3;2(78). doi: 10.3389/fgene.2011.00078.
MicroRNAs (miRNAs) are a class of non-coding small RNAs with critical regulatory functions as post-transcriptional regulators. Due to the fundamental importance and broad impact of miRNAs on multiple genes and pathways, dysregulated miRNAs have been associated with human diseases, including cancer. Colorectal cancer (CRC) is among the most deadly diseases, and miRNAs offer a new frontier for target discovery and novel biomarkers for both diagnosis and prognosis. In this review, we summarize the recent advancement of miRNA research in CRC, in particular, the roles of miRNAs in CRC stem cells, epithelial-to-mesenchymal transition, chemoresistance, therapeutics, diagnosis, and prognosis.
微小RNA（miRNA）是一类非编码小RNA，作为转录后调节因子具有关键的调节功能。由于miRNA对多个基因和通路具有根本重要性和广泛影响，其失调与包括癌症在内的人类疾病相关。结直肠癌（CRC）是最致命的疾病之一，而miRNA为靶点发现以及用于诊断和预后的新型生物标志物提供了新的领域。在本综述中，我们总结了CRC中miRNA研究的最新进展，特别是miRNA在CRC干细胞、上皮-间质转化、化疗耐药性、治疗、诊断和预后中的作用。
