细胞力学转导：细丝蛋白 A 应变调节运动。
Cellular mechanotransduction: filamin A strains to regulate motility.
机构信息
Department of Biological Sciences, Columbia University, New York, NY, USA.
出版信息
Curr Biol. 2011 Nov 22;21(22):R916-8. doi: 10.1016/j.cub.2011.10.020.
Abstract
A new study suggests that mechanical strain through the actin-binding protein filamin A leads to increased linkage between the extracellular matrix and cytoskeleton and decreased actin dynamics.
摘要
一项新的研究表明，通过肌动蛋白结合蛋白细丝蛋白 A 的机械张力导致细胞外基质和细胞骨架之间的连接增加，肌动蛋白动力学降低。
相似文献
1
Cellular mechanotransduction: filamin A strains to regulate motility.细胞力学转导：细丝蛋白 A 应变调节运动。
Curr Biol. 2011 Nov 22;21(22):R916-8. doi: 10.1016/j.cub.2011.10.020.
2
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.肌动蛋白网络中的机械应变调节 FilGAP 和整合素与细丝蛋白 A 的结合。
Nature. 2011 Sep 18;478(7368):260-3. doi: 10.1038/nature10430.
3
Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.Migfilin与细丝蛋白相互作用以及与整合素β尾竞争的结构基础。
J Biol Chem. 2008 Dec 12;283(50):35154-63. doi: 10.1074/jbc.M802592200. Epub 2008 Sep 30.
4
Alpha-actinin and filamin cooperatively enhance the stiffness of actin filament networks.α-辅肌动蛋白和细丝蛋白协同增强肌动蛋白丝网络的硬度。
PLoS One. 2009;4(2):e4411. doi: 10.1371/journal.pone.0004411. Epub 2009 Feb 9.
5
Migfilin, a molecular switch in regulation of integrin activation.Migfilin，一种调节整合素激活的分子开关。
J Biol Chem. 2009 Feb 13;284(7):4713-22. doi: 10.1074/jbc.M807719200. Epub 2008 Dec 13.
6
The molecular basis of filamin binding to integrins and competition with talin.细丝蛋白与整合素结合及与踝蛋白竞争的分子基础。
Mol Cell. 2006 Feb 3;21(3):337-47. doi: 10.1016/j.molcel.2006.01.011.
7
Filamins in mechanosensing and signaling.Filamins 在机械感知和信号转导中的作用。
Annu Rev Biophys. 2012;41:227-46. doi: 10.1146/annurev-biophys-050511-102252. Epub 2012 Feb 23.
8
The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin.人细丝蛋白A与整合素结合的自抑制调节机制。
J Mol Biol. 2009 Oct 30;393(3):644-57. doi: 10.1016/j.jmb.2009.08.035. Epub 2009 Aug 20.
9
Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells.细丝蛋白 A 控制基质金属蛋白酶活性并调节人纤维肉瘤细胞的细胞侵袭。
J Cell Sci. 2012 Aug 15;125(Pt 16):3858-69. doi: 10.1242/jcs.104018. Epub 2012 May 17.
10
Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.Migfilin和Mig-2将粘着斑与细丝蛋白及肌动蛋白细胞骨架相连，并在细胞形态调节中发挥作用。
Cell. 2003 Apr 4;113(1):37-47. doi: 10.1016/s0092-8674(03)00163-6.
引用本文的文献
1
A-to-I RNA editing of Filamin A regulates cellular adhesion, migration and mechanical properties.细丝蛋白 A 的 A-to-I RNA 编辑调控细胞黏附、迁移和力学特性。
FEBS J. 2022 Aug;289(15):4580-4601. doi: 10.1111/febs.16391. Epub 2022 Mar 9.
2
Role of chaperone-assisted selective autophagy (CASA) in mechanical stress protection of periodontal ligament cells.伴侣蛋白辅助的选择性自噬（CASA）在牙周韧带细胞机械应激保护中的作用。
J Orofac Orthop. 2022 Jan;83(1):1-12. doi: 10.1007/s00056-021-00358-3. Epub 2021 Nov 4.
3
Noncanonical function of long myosin light chain kinase in increasing ER-PM junctions and augmentation of SOCE.长肌球蛋白轻链激酶的非规范功能在于增加内质网-质膜连接点并增强 SOCE。
FASEB J. 2020 Sep;34(9):12805-12819. doi: 10.1096/fj.201902462RR. Epub 2020 Aug 9.
4
Melatonin and Hippo Pathway: Is There Existing Cross-Talk?褪黑素与 Hippo 通路：是否存在交叉对话？
Int J Mol Sci. 2017 Sep 6;18(9):1913. doi: 10.3390/ijms18091913.
5
Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.作用与牵引：免疫突触处受体触发的细胞骨架控制
Front Immunol. 2016 Mar 7;7:68. doi: 10.3389/fimmu.2016.00068. eCollection 2016.
6
Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix.细丝蛋白A通过促进胶原蛋白基质的弹性变形和张力维持来介导伤口闭合。
J Invest Dermatol. 2015 Nov;135(11):2852-2861. doi: 10.1038/jid.2015.251. Epub 2015 Jul 2.
7
Microfluidic Strategies for Understanding the Mechanics of Cells and Cell-Mimetic Systems.用于理解细胞及细胞模拟系统力学机制的微流控策略
Annu Rev Chem Biomol Eng. 2015;6:293-317. doi: 10.1146/annurev-chembioeng-061114-123407. Epub 2015 Jul 2.
本文引用的文献
1
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.肌动蛋白网络中的机械应变调节 FilGAP 和整合素与细丝蛋白 A 的结合。
Nature. 2011 Sep 18;478(7368):260-3. doi: 10.1038/nature10430.
2
Differential mechanical stability of filamin A rod segments.细丝蛋白 A 杆状结构域的机械稳定性差异。
Biophys J. 2011 Sep 7;101(5):1231-7. doi: 10.1016/j.bpj.2011.07.028.
3
Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin.整合素和迁移抑制因子通过黏着斑蛋白使配体在多个位点结合和伸展的证据。
Biochemistry. 2011 May 24;50(20):4229-31. doi: 10.1021/bi2003229. Epub 2011 Apr 27.
4
Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.细丝蛋白耗竭阻止内质网扩展并破坏力承载黏附。
Mol Biol Cell. 2011 Apr 15;22(8):1263-73. doi: 10.1091/mbc.E10-08-0661. Epub 2011 Feb 16.
5
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins.整合素黏着斑的定量蛋白质组学研究显示肌球蛋白 II 依赖性 LIM 结构域蛋白募集。
EMBO Rep. 2011 Mar;12(3):259-66. doi: 10.1038/embor.2011.5. Epub 2011 Feb 11.
6
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.伸展基质上的伸展蛋白：整合素介导的刚性感知的重要元素。
Dev Cell. 2010 Aug 17;19(2):194-206. doi: 10.1016/j.devcel.2010.07.018.
7
Force generated by actomyosin contraction builds bridges between adhesive contacts.肌动球蛋白收缩产生的力在黏附接触点之间形成桥。
EMBO J. 2010 Mar 17;29(6):1055-68. doi: 10.1038/emboj.2010.2. Epub 2010 Feb 11.
8
Cytoskeletal coherence requires myosin-IIA contractility.细胞骨架的连贯性需要肌球蛋白-IIA 的收缩性。
J Cell Sci. 2010 Feb 1;123(Pt 3):413-23. doi: 10.1242/jcs.058297. Epub 2010 Jan 12.
9
Filamins regulate cell spreading and initiation of cell migration.细丝蛋白调节细胞铺展和细胞迁移的起始。
PLoS One. 2009 Nov 13;4(11):e7830. doi: 10.1371/journal.pone.0007830.
10
The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin.人细丝蛋白A与整合素结合的自抑制调节机制。
J Mol Biol. 2009 Oct 30;393(3):644-57. doi: 10.1016/j.jmb.2009.08.035. Epub 2009 Aug 20.
Zotero 插件