新型苯并呋喃香豆素类似物的合成及其对人癌细胞系的抗增殖作用。
Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines.
机构信息
Chemistry Centre, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
出版信息
Eur J Med Chem. 2012 Jan;47(1):370-6. doi: 10.1016/j.ejmech.2011.11.005. Epub 2011 Nov 12.
PMID:22119152
Abstract
The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumor cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma) were evaluated, and discussed in terms of structure-activity relationship.
摘要
本文描述了五种新型四环苯并呋喃香豆素（苯并补骨脂素）类似物的合成。评估了它们对三种人肿瘤细胞系（MDA MB 231（乳腺癌）、HeLa（宫颈腺癌）和 TCC-SUP（膀胱移行细胞癌））生长的抑制作用，并根据构效关系进行了讨论。
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