Institute for Biological Research, University of Belgrade, Despota Stefana Blvd. 142, Belgrade, Serbia.
Behav Brain Res. 2012 Mar 17;228(2):241-6. doi: 10.1016/j.bbr.2011.10.046. Epub 2011 Nov 19.
The purpose of this study was to evaluate behavioural effects of an extremely low frequency magnetic field (ELF-MF) in 3-month-old Mongolian gerbils submitted to global cerebral ischemia. After 10-min occlusion of both common carotid arteries, the gerbils were placed in the vicinity of an electromagnet and continuously exposed to ELF-MF (50Hz, 0.5mT) for 7 days. Their behaviour (locomotion, stereotypy, rotations, and immobility) was monitored on days 1, 2, 4, 7, and 14 after reperfusion for 60min in the open field. It was shown that the 10-min global cerebral ischemia per se induced a significant motor activity increase (locomotion, stereotypy and rotations), and consequently immobility decrease until day 4 after reperfusion, compared to control gerbils. Exposure to ELF-MF inhibited development of ischemia-induced motor hyperactivity during the whole period of registration, but significantly in the first 2 days after reperfusion, when the postischemic hyperactivity was most evident. Motor activity of these gerbils was still significantly increased compared to control ones, but only on day 1 after reperfusion. Our results revealed that the applied ELF-MF (50Hz, 0.5mT) decreased motor hyperactivity induced by the 10-min global cerebral ischemia, via modulation of the processes that underlie this behavioural response.
本研究旨在评估极低频磁场（ELF-MF）对 3 月龄蒙古沙土鼠全脑缺血后行为的影响。双侧颈总动脉闭塞 10min 后，将沙土鼠置于电磁场附近，连续暴露于 ELF-MF（50Hz，0.5mT）中 7 天。在再灌注后第 1、2、4、7 和 14 天，于开放场中监测 60min 的行为（运动、刻板行为、旋转和不动）。结果显示，与对照组沙土鼠相比，10min 全脑缺血本身在再灌注后第 4 天之前会引起明显的运动活性增加（运动、刻板行为和旋转），进而导致不动性减少。与对照组相比，ELF-MF 抑制了缺血诱导的运动过度活跃，在再灌注后的前 2 天尤为明显。与对照组相比，这些沙土鼠的运动活性在再灌注后第 1 天仍显著增加，但仅在再灌注后第 1 天增加。我们的结果表明，施加的 ELF-MF（50Hz，0.5mT）通过调节这种行为反应的基础过程，降低了 10min 全脑缺血引起的运动过度活跃。
