Moya Gómez Amanda, Font Lena Pérez, Brône Bert, Bronckaers Annelies
UHasselt Hasselt University, BIOMED, Diepenbeek, Belgium.
Department of Biomedical Engineering, Faculty of Telecommunications, Informatics and Biomedical Engineering, Universidad de Oriente, Santiago de Cuba, Cuba.
Front Mol Biosci. 2021 Sep 7;8:742596. doi: 10.3389/fmolb.2021.742596. eCollection 2021.
Cerebral stroke is a leading cause of death and adult-acquired disability worldwide. To this date, treatment options are limited; hence, the search for new therapeutic approaches continues. Electromagnetic fields (EMFs) affect a wide variety of biological processes and accumulating evidence shows their potential as a treatment for ischemic stroke. Based on their characteristics, they can be divided into stationary, pulsed, and sinusoidal EMF. The aim of this review is to provide an extensive literature overview ranging from to even clinical studies within the field of ischemic stroke of all EMF types. A thorough comparison between EMF types and their effects is provided, as well as an overview of the signal pathways activated in cell types relevant for ischemic stroke such as neurons, microglia, astrocytes, and endothelial cells. We also discuss which steps have to be taken to improve their therapeutic efficacy in the frame of the clinical translation of this promising therapy.
脑卒中是全球范围内导致死亡和成人后天残疾的主要原因。迄今为止，治疗选择有限；因此，对新治疗方法的探索仍在继续。电磁场（EMF）影响多种生物过程，越来越多的证据表明其具有治疗缺血性脑卒中的潜力。根据其特性，可分为静态、脉冲和正弦电磁场。本综述的目的是提供一个广泛的文献概述，涵盖缺血性脑卒中领域内从……到甚至临床研究的所有电磁场类型。提供了电磁场类型及其效应之间的全面比较，以及在与缺血性脑卒中相关的细胞类型（如神经元、小胶质细胞、星形胶质细胞和内皮细胞）中激活的信号通路概述。我们还讨论了在这种有前景的治疗方法的临床转化框架内，为提高其治疗效果必须采取哪些步骤。
