上皮样垂体细胞瘤。
Epithelioid pituicytoma.
机构信息
Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
出版信息
World Neurosurg. 2012 Jul;78(1-2):191.E1-7. doi: 10.1016/j.wneu.2011.09.011. Epub 2011 Nov 7.
BACKGROUND
Pituicytomas are rare tumors of the sellar region that are derived from specialized glial cells called pituicytes. They characteristically exhibit spindle-cell features and fascicular or storiform patterns of growth. No other histological variants of this tumor have been described.
CASE DESCRIPTION
Here we report a diagnostically challenging case of pituicytoma in a 42-year-old man with a sellar mass arising from the pituitary stalk. On histological examination, the tumor displayed an epithelioid histoarchitecture with no characteristic spindle-cell or fascicular growth features. Strong immunopositivity for the pituicyte marker thyroid transcription factor-1 within tumor cells proved essential for diagnosing this unusual pituicytoma variant.
CONCLUSION
Pituicytomas may display epithelioid rather than fascicular or storiform histoarchitecture. Epithelioid pituicytoma variants may be diagnosed in cases such as ours in which both the clinical findings and immunohistochemical analysis suggest a tumor derived from pituicytes.
背景
垂体细胞瘤是一种罕见的鞍区肿瘤，来源于称为垂体细胞的特殊神经胶质细胞。它们具有典型的梭形细胞特征和束状或索状生长模式。这种肿瘤没有其他组织学变异型。
病例描述
我们在此报告一例具有挑战性的垂体细胞瘤病例，患者为 42 岁男性，鞍区垂体柄处有一肿块。组织学检查显示，肿瘤具有上皮样组织形态，没有特征性的梭形细胞或束状生长特征。肿瘤细胞中强烈表达垂体细胞标志物甲状腺转录因子-1，这对于诊断这种不常见的垂体细胞瘤变异型至关重要。
结论
垂体细胞瘤可能表现为上皮样而非束状或索状组织形态。上皮样垂体细胞瘤变异型可能在临床发现和免疫组织化学分析均提示肿瘤来源于垂体细胞的情况下被诊断出来，就像我们的病例一样。
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