Department of Pathology, Air Force Central Medical Establishment, Subroto Park, New Delhi, India.
Department of Pathology and Molecular Medicine, Army Hospital Research and Referral, Delhi Cantt, New Delhi, India.
Indian J Pathol Microbiol. 2021 Jan-Mar;64(1):145-148. doi: 10.4103/IJPM.IJPM_430_20.
Pituicytoma is a distinct sellar or supracellar tumor which originates from specialized glial cells of neurohypophyses and infundibulum known as pituicytes. Because of its sellar location patients present with headache, visual disturbance, and endocrine abnormalities. Pituicytoma is difficult to diagnose on neuroimaging as radiological features overlap with other more common tumors of this region. Thus, diagnosis is established by histopathology and immunohistochemistry of resected tumor only. Pituicytomas are composed of bipolar spindle cells arranged as fascicles and are immunoreactive for TTF-1, S100p, and vimentin. These tumors are extremely rare and only around 70 published cases are known in literature. We report a case of suprasellar SOL in a 58-year-old male who presented with headache and gradual visual deterioration in both eyes. He was diagnosed as a case of pituicytoma based on light microscopy findings and immunohistochemical expression of TTF-1, vimentin, S100p, and bcl-2.
垂体细胞瘤是一种起源于神经垂体和漏斗部的特殊神经胶质细胞(即垂体细胞)的独特鞍内或鞍上肿瘤。由于其鞍内位置,患者表现为头痛、视力障碍和内分泌异常。由于影像学特征与该区域更常见的肿瘤重叠,因此垂体细胞瘤在神经影像学上难以诊断。因此,诊断仅通过切除肿瘤的组织病理学和免疫组织化学来确定。垂体细胞瘤由排列成束的双极梭形细胞组成,对 TTF-1、S100p 和波形蛋白呈免疫反应性。这些肿瘤极为罕见,文献中仅报道了约 70 例。我们报告了一例 58 岁男性的鞍上 SOL,他因头痛和双眼逐渐视力恶化而就诊。根据光镜检查结果和 TTF-1、波形蛋白、S100p 和 bcl-2 的免疫组织化学表达,他被诊断为垂体细胞瘤。