用于测量抗生素对链球菌心内膜炎菌株作用效果的多重断点法

Multiple breakpoint method for measuring effect of antibiotics on endocarditis strains of streptococci.

作者信息

Marks J, Paull A

机构信息

Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff.

出版信息

J Clin Pathol. 1990 Sep;43(9):774-6. doi: 10.1136/jcp.43.9.774.

DOI:10.1136/jcp.43.9.774

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC502760/

Abstract

The activity of penicillin alone and combined with aminoglycoside on endocarditis strains of streptococci was examined. Good assay reproducibility was obtained by the use of logarithmic phase cultures standardised by opacity, careful inoculation of well-plates, removal of antibiotic by membrane transfer and incubating survival counts in hydrogen plus carbon dioxide. The use of 10-fold intervals for penicillin concentration simplified assay design without loss of efficiency.

摘要

研究了青霉素单独使用以及与氨基糖苷类联合使用对链球菌心内膜炎菌株的活性。通过使用经浊度标准化的对数期培养物、小心接种微孔板、通过膜转移去除抗生素以及在氢气加二氧化碳中培养存活计数，获得了良好的测定重现性。青霉素浓度采用10倍间隔使用简化了测定设计且不损失效率。

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本文引用的文献

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The role of the laboratory in assisting treatment--a review of current UK practices.

J Antimicrob Chemother. 1987 Sep;20 Suppl A:51-70. doi: 10.1093/jac/20.suppl_a.51.

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A new method for the determination of bactericidal antibiotic synergy.一种测定杀菌性抗生素协同作用的新方法。

J Antimicrob Chemother. 1987 Dec;20(6):831-8. doi: 10.1093/jac/20.6.831.

3

The role of the microbiology laboratory in the treatment of infective endocarditis.

J Antimicrob Chemother. 1987 Sep;20 Suppl A:41-9. doi: 10.1093/jac/20.suppl_a.41.

4

Effect of penicillin on endocarditis strains of viridans streptococci.青霉素对草绿色链球菌心内膜炎菌株的作用。

J Clin Pathol. 1989 Oct;42(10):1114-5. doi: 10.1136/jcp.42.10.1114.

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