Lipids and Atherosclerosis Research Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos, Córdoba, Spain.
Mol Nutr Food Res. 2012 Jan;56(1):171-83. doi: 10.1002/mnfr.201100513. Epub 2011 Nov 25.
It is well known that lipid metabolism is a cornerstone in the development of the commonest important chronic diseases worldwide, such as obesity, cardiovascular disease, or metabolic syndrome. In this regard, the area of lipid and lipoprotein metabolism is one of the areas in which the understanding of the development and progression of those metabolic disorders has been studied in greater depth. Thus, growing evidence has demonstrated that while universal recommendations might be appropriate for the general population, in this area there is great variability among individuals, related to a combination of environmental and genetic factors. Moreover, the interaction between genetic and dietary components has helped in understanding this variability. Therefore, with further study into the interaction between the most important genetic markers or single-nucleotide polymorphisms (SNPs) and diet, it may be possible to understand the variability in lipid metabolism, which could lead to an increase in the use of personalized nutrition as the best support to combat metabolic disorders. This review discusses some of the evidence in which candidate SNPs can affect the key players of lipid metabolism and how their phenotypic manifestations can be modified by dietary intake.
众所周知，脂质代谢是全世界最常见的重要慢性疾病（如肥胖、心血管疾病或代谢综合征）发展的基石。在这方面，脂质和脂蛋白代谢领域是深入研究这些代谢紊乱发生和发展的领域之一。因此，越来越多的证据表明，虽然普遍的建议可能适用于一般人群，但在这方面，个体之间存在很大的差异，这与环境和遗传因素的综合作用有关。此外，遗传和饮食成分之间的相互作用有助于理解这种可变性。因此，随着对最重要的遗传标记或单核苷酸多态性（SNP）与饮食之间相互作用的进一步研究，我们可能能够了解脂质代谢的可变性，这可能导致个性化营养的使用增加，作为对抗代谢紊乱的最佳支持。这篇综述讨论了一些候选 SNP 可以影响脂质代谢关键因子的证据，以及它们的表型表现如何可以通过饮食摄入来改变。
