Postgraduate Program in Health Science, Federal University of Rio Grande do Norte, Av. Nilo Peçanha 620, Petropolis, Natal, RN, 59012-300, Brazil.
Department of Physical Education, Federal University of Rio Grande do Norte, Campus Universitario, Lagoa Nova, Natal, RN, 59078-900, Brazil.
BMC Complement Altern Med. 2019 Aug 6;19(1):202. doi: 10.1186/s12906-019-2620-7.
Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable alternative for HIV-infected individuals. The aim of this study is to evaluate the influence of curcumin supplementation on substrate oxidation at rest, body composition, and the lipid profile of physically active people living with HIV/AIDS under antiretroviral therapy.
This double-blind, crossover, randomized clinical trial was comprised of 20 subjects divided into experimental (EG) and control (CG) groups, receiving 1000 mg curcumin/day and placebo, respectively, during a 30-day period. Substrate oxidation at rest was assessed by indirect calorimetry, body composition was measured by dual-energy x-ray absorptiometry, and the lipid profile was evaluated by blood tests. Data analysis was performed by independent samples and paired t-tests to compare the differences between groups and times. A p-value < 0.05 was accepted as significant.
There were no differences between groups regarding substrate oxidation at rest or body composition. However, serum triglyceride levels were increased after curcumin supplementation (182 vs. 219 mg/dL; p = 0.004).
Curcumin supplementation promoted the elevation of serum triglyceride levels in HIV-infected subjects. Further studies with a larger sample cohort, different curcumin doses, and longer intervention times are needed to validate current observations. In addition, the influence of physical activity, dietary intake, and genetic polymorphisms must be considered in future studies to better understand the impact of curcumin supplementation on the lipid profile of people living with HIV/AIDS under antiretroviral therapy.
科学研究表明，姜黄素在几种疾病中的潜在治疗功效归因于其强大的抗氧化和抗炎特性。因此，姜黄素补充剂似乎是感染艾滋病毒的个体的一种有价值的替代选择。本研究旨在评估姜黄素补充对接受抗逆转录病毒治疗的艾滋病毒/艾滋病感染者的静息时底物氧化、身体成分和血脂谱的影响。
这是一项双盲、交叉、随机临床试验，共纳入 20 名受试者，分为实验组（EG）和对照组（CG），分别在 30 天内每天接受 1000mg 姜黄素和安慰剂。通过间接热量法评估静息时的底物氧化，通过双能 X 射线吸收法测量身体成分，通过血液测试评估血脂谱。数据分析采用独立样本和配对 t 检验比较组间和时间差异。p 值<0.05 被认为具有统计学意义。
静息时底物氧化或身体成分在组间无差异。然而，姜黄素补充后血清甘油三酯水平升高（182 与 219mg/dL；p=0.004）。
姜黄素补充剂可升高感染艾滋病毒个体的血清甘油三酯水平。需要进一步开展具有更大样本量、不同姜黄素剂量和更长干预时间的研究来验证当前的观察结果。此外，必须考虑身体活动、饮食摄入和遗传多态性的影响，以便更好地了解姜黄素补充对接受抗逆转录病毒治疗的艾滋病毒/艾滋病感染者的血脂谱的影响。
