全反式维甲酸治疗急性早幼粒细胞白血病后出现的阴囊溃疡
Scrotal ulceration following all-trans retinoic Acid therapy for acute promyelocytic leukemia.
作者信息
Tazi Illias, Rachid Mohamed, Quessar Asmaa, Benchekroun Said
机构信息
Department of Hematology and Pediatric Oncology, Hopital 20 Aout 1953, rue Lahcen Laarjoune Casablanca, Morocco.
出版信息
Indian J Dermatol. 2011 Sep-Oct;56(5):561-3. doi: 10.4103/0019-5154.87156.
Abstract
All-trans retinoic acid (ATRA) induces complete remission in most cases of acute promyelocytic leukemia. Toxicity of ATRA has been shown to be mild, consisting of headache, dry skin, dermatitis, and gastrointestinal disorders. We describe a case of scrotal ulceration with ATRA use in a Moroccan patient, an occurrence that has been rarely reported in the medical literature. The pathogenesis of scrotal ulceration remains unknown. Our experience indicates the importance of recognizing genital ulcers associated with ATRA in order that appropriate countermeasures can be taken.
摘要
全反式维甲酸（ATRA）可使大多数急性早幼粒细胞白血病病例实现完全缓解。已表明ATRA的毒性较轻微，包括头痛、皮肤干燥、皮炎和胃肠道紊乱。我们描述了一名摩洛哥患者使用ATRA后出现阴囊溃疡的病例，这一情况在医学文献中鲜有报道。阴囊溃疡的发病机制尚不清楚。我们的经验表明认识到与ATRA相关的生殖器溃疡非常重要，以便能够采取适当的应对措施。
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