全反式维甲酸治疗急性早幼粒细胞白血病患者的生殖器溃疡形成：病例系列
Genital ulcer development in patients with acute promyelocytic leukaemia treated with all-trans retinoic Acid: a case series.
作者信息
Al Huneini Mohammed, Wasim Fauzia, Al Farsi Khalil, Al-Khabori Murtadha, Al Kindi Salam
机构信息
Department of Hematology, Sultan Qaboos University Hospital, Al-Khoud, P.O.Box 35 Muscat 123, Sultanate of Oman.
出版信息
Oman Med J. 2013 May;28(3):207-9. doi: 10.5001/omj.2012.56.
Abstract
We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.
摘要
我们在此报告4例在使用全反式维甲酸（ATRA）治疗急性早幼粒细胞白血病（APL）后出现生殖器溃疡的病例。在2007年10月至2010年3月期间，3名男性和1名女性（年龄范围19 - 35岁）在被处方使用全反式维甲酸（ATRA）作为APL化疗的一部分后，被发现患有生殖器溃疡。这是首例描述生殖器溃疡的病例系列，该溃疡是这些患者使用ATRA治疗APL时一种独特且罕见的并发症，未发现其他病因。在这3例病例中暂时停用ATRA几天后，发现溃疡有所改善。
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