含壳聚糖/纳米羟基磷灰石/纳米铜锌的生物复合支架用于骨组织工程。
Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering.
机构信息
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu, India.
出版信息
Int J Biol Macromol. 2012 Jan 1;50(1):294-9. doi: 10.1016/j.ijbiomac.2011.11.013. Epub 2011 Nov 23.
The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.
本研究通过冷冻干燥技术制备了含有壳聚糖（CS）、纳米羟基磷灰石（nHAp）和铜锌合金纳米粒子（nCu-Zn）的生物复合材料支架，并对其进行了表征。通过 SEM、EDX、XRD 和 FT-IR 研究对制备的复合支架（CS/nHAp 和 CS/nHAp/nCu-Zn）进行了表征。在 CS/nHAp 支架中添加 nCu-Zn 显著提高了溶胀性、降低了降解性、增加了蛋白质吸附性、提高了抗菌活性。CS/nHAp/nCu-Zn 支架对大鼠成骨前体细胞没有毒性。因此，与 CS-nHAp 支架相比，开发的 CS/nHAp/nCu-Zn 支架在骨组织工程中具有优势和潜在应用。
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