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龙蒿精油对掺杂羟基磷灰石/壳聚糖生物复合材料特性的影响研究

Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites.

作者信息

Predoi Daniela, Iconaru Simona Liliana, Ciobanu Carmen Steluta, Raita Mariana Stefania, Ghegoiu Liliana, Trusca Roxana, Badea Monica Luminita, Cimpeanu Carmen

机构信息

National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania.

Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 105 Splaiul Independentei, District 5, 050097 Bucharest, Romania.

出版信息

Polymers (Basel). 2023 Apr 16;15(8):1908. doi: 10.3390/polym15081908.

DOI:10.3390/polym15081908
PMID:37112055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10142985/
Abstract

Due to the emergence of antibiotic-resistant pathogens, the need to find new, efficient antimicrobial agents is rapidly increasing. Therefore, in this study, we report the development of new biocomposites based on zinc-doped hydroxyapatite/chitosan enriched with essential oil of L. with good antimicrobial activity. Techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) were used in order to evaluate their physico-chemical properties. Our studies revealed that biocomposite materials with nanometric dimension and homogeneous composition could be obtained through an economic and cost-effective synthesis method. The biological assays demonstrated that ZnHA (zinc-doped hydroxyapatite), ZnHACh (zinc-doped hydroxyapatite/chitosan) and ZnHAChT (zinc-doped hydroxyapatite/chitosan enriched with essential oil of L.) did not exhibit a toxic effect on the cell viability and proliferation of the primary osteoblast culture (hFOB 1.19). Moreover, the cytotoxic assay also highlighted that the cell morphology of the hFOB 1.19 was not altered in the presence of ZnHA, ZnHACh or ZnHAChT. Furthermore, the in vitro antimicrobial studies emphasized that the samples exhibited strong antimicrobial properties against ATCC 25922, ATCC 25923 and ATCC 10231 microbial strains. These results are encouraging for the following development of new composite materials with enhanced biological properties that could promote the osteogenic process of bone healing and also exhibit good antimicrobial properties.

摘要

由于抗生素抗性病原体的出现，寻找新型高效抗菌剂的需求正在迅速增加。因此，在本研究中，我们报告了基于掺杂锌的羟基磷灰石/壳聚糖并富含罗勒精油的新型生物复合材料的开发，该复合材料具有良好的抗菌活性。使用扫描电子显微镜（SEM）、X射线衍射（XRD）、能量色散X射线光谱（EDX）和傅里叶变换红外光谱（FTIR）等技术来评估其物理化学性质。我们的研究表明，通过一种经济且具有成本效益的合成方法可以获得具有纳米尺寸和均匀组成的生物复合材料。生物学试验表明，ZnHA（掺杂锌的羟基磷灰石）、ZnHACh（掺杂锌的羟基磷灰石/壳聚糖）和ZnHAChT（掺杂锌的羟基磷灰石/壳聚糖并富含罗勒精油）对原代成骨细胞培养物（hFOB 1.19）的细胞活力和增殖没有毒性作用。此外，细胞毒性试验还突出表明，在存在ZnHA、ZnHACh或ZnHAChT的情况下，hFOB 1.19的细胞形态没有改变。此外，体外抗菌研究强调，这些样品对ATCC 25922、ATCC 25923和ATCC 10231微生物菌株表现出很强的抗菌性能。这些结果对于开发具有增强生物学特性的新型复合材料是令人鼓舞的，这些复合材料可以促进骨愈合的成骨过程，并且还具有良好的抗菌性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/fea7ab6d6dcb/polymers-15-01908-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/7cf59d399461/polymers-15-01908-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/7ccdb0bce4b5/polymers-15-01908-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/990ff1398146/polymers-15-01908-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/d392044ce377/polymers-15-01908-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/8ca74178845f/polymers-15-01908-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/96f4761ba881/polymers-15-01908-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/a9c38b9f9f49/polymers-15-01908-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/fea7ab6d6dcb/polymers-15-01908-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/7cf59d399461/polymers-15-01908-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/3a414121e4ac/polymers-15-01908-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/7ccdb0bce4b5/polymers-15-01908-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/990ff1398146/polymers-15-01908-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/d392044ce377/polymers-15-01908-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/8ca74178845f/polymers-15-01908-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/96f4761ba881/polymers-15-01908-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/a9c38b9f9f49/polymers-15-01908-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c9/10142985/fea7ab6d6dcb/polymers-15-01908-g009.jpg

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