Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Ave., South, A5102 MCN, Nashville, TN 37232-2363, USA.
Microbes Infect. 2012 Mar;14(3):217-27. doi: 10.1016/j.micinf.2011.11.001. Epub 2011 Nov 15.
The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently most living organisms, including pathogenic bacteria, require iron to survive and replicate. To combat infection vertebrates have evolved sophisticated iron sequestration systems against which, pathogenic bacteria have concomitantly evolved equally elaborate iron acquisition mechanisms.
铁作为一种酶的辅因子在生物系统中被广泛使用。因此，包括致病菌在内的大多数生物都需要铁来生存和繁殖。为了对抗感染，脊椎动物进化出了复杂的铁螯合系统，而致病菌则相应地进化出了同样复杂的铁获取机制。
