Abbasi S, Ludomirski A, Bhutani V K, Weiner S, Johnson L
University of Pennsylvania, School of Medicine, Philadelphia.
J Am Coll Nutr. 1990 Aug;9(4):314-9. doi: 10.1080/07315724.1990.10720386.
Placental transfer of vitamin E was investigated from 19 to 35 weeks of gestation by analysis of fetal and maternal blood samples for total tocopherol, total lipids, and fetal red blood cell antioxidant reserves. Fifty-two fetal blood samples were obtained under ultrasonographic guide by percutaneous umbilical blood sampling. Thirteen were from fetuses with gestational age less than or equal to 22 weeks (x serum vitamin E = 0.4 +/- 0.14 mg/dl), 12 were from fetuses at 23-27 weeks gestation (x serum vitamin E = 0.4 +/- 0.21 mg/dl), and 27 were from fetuses with gestational age 28-38 weeks (x serum level = 0.37 +/- 0.18). Total lipid levels ranged from 140 to 216 mg/dl. Maternal plasma vitamin E concentrations correlated significantly with concurrent values in the fetus. There were no significant differences in serum vitamin E levels or vitamin E to total lipid ratio in samples from early, mid, or late gestation in either the mother or fetus. Red blood cell antioxidant reserve on samples from 18 fetuses were grossly abnormal by three different functional assays. On the basis of these data, placental transfer of vitamin E appears to be relatively constant through advancing gestation. Red blood cell antioxidant reserve is uniformly low.
通过分析胎儿和母体血样中的总生育酚、总脂质以及胎儿红细胞抗氧化储备，研究了妊娠19至35周期间维生素E的胎盘转运情况。在超声引导下，通过经皮脐血采样获取了52份胎儿血样。其中13份来自孕周小于或等于22周的胎儿（血清维生素E平均值 = 0.4 ± 0.14毫克/分升），12份来自妊娠23 - 27周的胎儿（血清维生素E平均值 = 0.4 ± 0.21毫克/分升），27份来自孕周28 - 38周的胎儿（血清水平平均值 = 0.37 ± 0.18）。总脂质水平在140至216毫克/分升之间。母体血浆维生素E浓度与胎儿同期值显著相关。在母亲或胎儿中，早、中、晚期妊娠样本的血清维生素E水平或维生素E与总脂质的比值均无显著差异。通过三种不同的功能测定，18份胎儿样本的红细胞抗氧化储备严重异常。基于这些数据，随着孕周增加，维生素E的胎盘转运似乎相对恒定。红细胞抗氧化储备始终较低。
