Cachia O, Léger C L, Boulot P, Vernet M H, Michel F, Crastes de Paulet A, Descomps B
Institut National de la Santé et de la Recherche Médicale, Centre Hospitalo-Universitaire de Montpellier.
Am J Obstet Gynecol. 1995 Jul;173(1):42-51. doi: 10.1016/0002-9378(95)90167-1.
The purpose was to establish which blood characteristic of vitamin E status were highly correlated between mothers and fetuses during gestation.
Twenty-four pregnant women were selected because of suspicion of toxoplasmosis or other disease and malformation or intrauterine growth delay justifying cord blood puncture. After maternal and fetal blood was collected, analyses of plasma and red blood cell vitamin E contents were performed together with analyses of standard lipid parameters and lipoprotein (a) in maternal plasma and fatty acid compositions of maternal and fetal red blood cells.
The maternal population was characterized by a plasma lipid-normalized vitamin E mean content higher (3.5 mmol/mol lipids) than usually found in nonpregnant adults. There was no relationship between plasma and red blood cell vitamin E contents. This was also true for fetuses. When the vitamin E status of mothers was compared with that of fetuses, we found no correlation in plasma vitamin E in the whole population and in the high lipoprotein (a) (> 300 mg/L) and low lipoprotein (a) (< 300 mg/L) groups. In contrast, statistically significant correlations appeared between maternal and fetal red blood cell contents and red blood cell relative charges in vitamin E in the whole population, whereas still higher correlations occurred in the high lipoprotein (a) group (r = 0.94 for the red blood cell content). Improved correlations were also found in the high lipoprotein (a) group for the interrelationship between vitamin E and plasma lipid contents (cholesterol and triglycerides), whereas improvement was noted in the low lipoprotein (a) group by positive correlation between age and vitamin E red blood cell content or red blood cell relative charge.
Determination of red blood cell vitamin E and plasma lipoprotein (a) in mothers could be useful in antenatal blood analysis in cases of risk of prematurity at birth, to prevent peroxidative membrane damage in neonates, and > 85% of the mothers in the current population would benefit from vitamin E supplementation from the viewpoint of the fetal red blood cell vitamin E requirement in spite of the rather high maternal lipid-normalized vitamin E plasma content.
本研究旨在确定孕期母婴之间哪些血液中维生素E状态特征具有高度相关性。
选取24名孕妇，她们因怀疑患有弓形虫病或其他疾病、胎儿畸形或宫内生长迟缓而需要进行脐血穿刺。采集母血和胎儿血后，对血浆和红细胞中的维生素E含量进行分析，并同时分析母体血浆中的标准脂质参数和脂蛋白(a)以及母胎红细胞的脂肪酸组成。
母体人群的血浆脂质标准化维生素E平均含量较高(3.5 mmol/mol脂质)，高于非孕期成年人的常见水平。血浆和红细胞中的维生素E含量之间没有关系。胎儿的情况也是如此。当比较母亲和胎儿的维生素E状态时，我们发现总体人群以及高脂蛋白(a)(> 300 mg/L)和低脂蛋白(a)(< 300 mg/L)组的血浆维生素E均无相关性。相反，总体人群中母胎红细胞含量与红细胞中维生素E的相对电荷之间存在统计学显著相关性，而在高脂蛋白(a)组中相关性更高(红细胞含量的r = 0.94)。高脂蛋白(a)组中维生素E与血浆脂质含量(胆固醇和甘油三酯)之间的相互关系也有更好的相关性，而在低脂蛋白(a)组中，年龄与维生素E红细胞含量或红细胞相对电荷之间呈正相关，相关性有所改善。
对于有早产风险的病例，测定母亲红细胞中的维生素E和血浆脂蛋白(a)有助于产前血液分析，以预防新生儿的过氧化膜损伤。尽管母体血浆中脂质标准化维生素E含量相当高，但从胎儿红细胞对维生素E的需求来看，目前人群中超过85%的母亲将从维生素E补充剂中受益。
