Departamento de Epidemiologia, Universidade de São Paulo, São Paulo, Brasil.
Rev Saude Publica. 2011 Dec;45(6):1062-71. doi: 10.1590/s0034-89102011000600008.
To develop a model to assess different strategies of pertussis booster vaccination in the city of São Paulo.
A dynamic stationary age-dependent compartmental model with waning immunity was developed. The "Who Acquires Infection from Whom" matrix was used to modeling age-dependent transmission rates. There were tested different strategies including vaccine boosters to the current vaccination schedule and three of them were reported: (i) 35% coverage at age 12, or (ii) 70% coverage at age 12, and (iii) 35% coverage at age 12 and 70% coverage at age 20 at the same time.
The strategy (i) achieved a 59% reduction of pertussis occurrence and a 53% reduction in infants while strategy (ii) produced 76% and 63% reduction and strategy (iii) 62% and 54%, respectively.
Pertussis booster vaccination at age 12 proved to be the best strategy among those tested in this study as it achieves the highest overall reduction and the greatest impact among infants who are more susceptible to pertussis complications.
在圣保罗市开发一种评估百日咳加强免疫接种不同策略的模型。
建立了一个具有衰减免疫力的动态固定年龄依赖性房室模型。使用“谁从谁那里获得感染”矩阵来对年龄依赖性传播率进行建模。测试了不同的策略，包括对当前疫苗接种计划进行疫苗加强，并报告了其中三种策略：（i）在 12 岁时覆盖 35%，或（ii）在 12 岁时覆盖 70%，以及（iii）在 12 岁时覆盖 35%，同时在 20 岁时覆盖 70%。
策略（i）使百日咳的发生减少了 59%，婴儿的发生减少了 53%，而策略（ii）使发生减少了 76%和 63%，策略（iii）使发生减少了 62%和 54%。
在本研究中测试的策略中，12 岁时进行百日咳加强免疫接种被证明是最佳策略，因为它在婴儿中实现了最高的总体减少和最大的影响，而婴儿更容易受到百日咳并发症的影响。
