Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Int J Hyperthermia. 2010;26(7):699-709. doi: 10.3109/02656736.2010.493915.
This paper reviews systems and techniques to deliver simultaneous thermoradiotherapy of breast cancer. It first covers the clinical implementation of simultaneous delivery of superficial (microwave or ultrasound) hyperthermia and external photon beam radiotherapy, first using a Cobalt-60 teletherapy unit and later medical linear accelerators. The parallel development and related studies of the Scanning Ultrasound Reflector Linear Arrays System (SURLAS), an advanced system specifically designed and developed for simultaneous thermoradiotherapy, follows. The performance characteristics of the SURLAS are reviewed and power limitation problems at high acoustic frequencies (>3 MHz) are discussed along with potential solutions. Next, the feasibility of simultaneous SURLAS hyperthermia and intensity modulated radiation therapy/image-guided radiotherapy (IMRT/IGRT) is established based on published and newly presented studies. Finally, based on the encouraging clinical results thus far, it is concluded that new trials employing the latest technologies are warranted along with further developments in treatment planning.
本文回顾了用于乳腺癌同步热放疗的系统和技术。它首先介绍了浅表（微波或超声）热疗和外照射光子束放疗同时进行的临床实施，最初使用钴-60 远距离治疗机，后来使用医用直线加速器。接下来介绍了专门设计用于同步热放疗的先进系统——超声反射线性阵列扫描系统（SURLAS）的平行发展和相关研究。文中回顾了 SURLAS 的性能特点，并讨论了在高声波频率（>3 MHz）下的功率限制问题及潜在的解决方案。然后，根据已发表和新提出的研究，证实了 SURLAS 热疗与强度调制放射治疗/图像引导放射治疗（IMRT/IGRT）同步的可行性。最后，鉴于目前令人鼓舞的临床结果，作者认为有必要开展新的试验，采用最新技术，并进一步改进治疗计划。
