The Medical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
J Affect Disord. 2012 Feb;136(3):443-52. doi: 10.1016/j.jad.2011.11.005. Epub 2011 Nov 29.
The hopelessness theory of depression posits that individuals with negative cognitive styles are at an increased risk for depression following negative life events. In neuroimaging studies, brain gray matter volume abnormalities correlate with the presence of depressive disorders. However, it is unknown whether changes in gray matter volume also appear in healthy individuals with cognitive vulnerability to depression (CVD).
30 subjects diagnosed with CVD, 33 first-episode patients with major depressive disorder (MDD), and 32 healthy controls were examined using voxel-based morphometry following magnetic resonance imaging (MRI).
We found significant volumetric differences between three groups in the left precentral gyrus, right fusiform gyrus and the right thalamus. In these regions, compared to controls, CVD subjects showed reduced gray matter volumes in the left precentral gyrus and right fusiform gyrus. MDD patients demonstrated reduced gray matter volume in the left precentral gyrus and increased gray matter volume in the right thalamus. Additionally, CVD individuals had significantly smaller right fusiform gyrus and right thalamus than MDD patients. The weakest-link scores on CSQ were negatively correlated with gray matter volumes in the left precentral gyrus.
Reductions in brain gray matter volume exist widely in individuals with CVD. In addition, there exist similar abnormalities in gray matter volume in both CVD subjects and MDD patients. Reductions of gray matter volume in the left precentral gyrus might be correlated to the negative cognitive styles, as well as an increased risk for depression.
抑郁症的无望理论认为，具有消极认知风格的个体在经历负面生活事件后，患抑郁症的风险增加。在神经影像学研究中，大脑灰质体积异常与抑郁障碍的存在相关。然而，尚不清楚灰质体积的变化是否也会出现在具有抑郁认知脆弱性（CVD）的健康个体中。
对 30 名被诊断为 CVD 的患者、33 名首发重性抑郁障碍（MDD）患者和 32 名健康对照者进行磁共振成像（MRI）后基于体素的形态学分析。
我们发现三组之间在左中央前回、右梭状回和右丘脑存在明显的体积差异。与对照组相比，CVD 患者的左中央前回和右梭状回灰质体积减少，MDD 患者的左中央前回灰质体积减少，右丘脑灰质体积增加。此外，CVD 患者的右侧梭状回和右侧丘脑明显小于 MDD 患者。CSQ 的最薄弱环节评分与左中央前回的灰质体积呈负相关。
CVD 患者的大脑灰质体积普遍减少。此外，CVD 患者和 MDD 患者的灰质体积也存在类似的异常。左中央前回灰质体积减少可能与消极认知风格以及抑郁风险增加有关。
