Department of Radiology, Fujian Medical University Teaching Hospital, Fujian Provincial Cancer Hospital, 350014, Fujian, P.R. China.
Magn Reson Imaging. 2012 Feb;30(2):165-70. doi: 10.1016/j.mri.2011.09.019. Epub 2011 Nov 30.
At present, accurate assessment of therapeutic efficacy at the early stage of treatment is still a challenge for radiologists. As a new non-radiation whole body imaging technology, Whole body-diffusion weighted imaging (WB-DWI) had shown promising application prospects in therapeutic assessment, which confirmed by many premier animal studies. Here we report that in the chemotherapeutic assessment of malignant non-Hodgkin's lymphoma, WB-DWI can not only detect the morphological change of solid infiltrated lesion as the convention (such as CT, PET, etc.) but also provide information about the growth and decline process of tumor cells in the lesion combining with the dynamic changes of apparent diffusion coefficient (ADC) value, which is sooner than the morphological changes.
目前，准确评估治疗早期的疗效仍然是放射科医生面临的挑战。全身弥散加权成像（WB-DWI）作为一种新的非放射性全身成像技术，在治疗评估方面显示出了广阔的应用前景，这已得到许多一流的动物研究的证实。在这里，我们报告在恶性非霍奇金淋巴瘤的化疗评估中，WB-DWI 不仅可以检测到实体浸润性病变的形态变化，如常规（如 CT、PET 等），而且还可以结合表观扩散系数（ADC）值的动态变化提供关于病变中肿瘤细胞生长和消退过程的信息，这比形态变化更早。
