Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Epilepsy Behav. 2012 Jan;23(1):47-51. doi: 10.1016/j.yebeh.2011.10.010. Epub 2011 Dec 1.
Health-related quality of life (HRQOL) is associated with seizure recency among adults with epilepsy. In a prospective, community-based study of long-term outcomes of childhood-onset epilepsy, we evaluated whether worse HRQOL is associated with more recent seizures among children and adolescents with epilepsy. We used the Child Health Questionnaire (CHQ), a generic measure with child and parent-proxy versions, to measure HRQOL. Among 277 children with epilepsy (CWE) assessed 9 years after diagnosis, parent-proxy reported but not child self-reported HRQOL was significantly worse for those having seizures in the prior year than for those who were seizure free ≥1 year across the majority of scales. There were no differences between CWE in remission for 1-5 years and those seizure free ≥5 years for child and parent-proxy reported HRQOL with the exception of the parent Emotional Impact scale, suggesting that HRQOL differences related to seizure recency level off after the initial year of remission.
健康相关生活质量（HRQOL）与成年人癫痫发作的近期情况有关。在一项针对儿童期起病癫痫长期结局的前瞻性、社区为基础的研究中，我们评估了癫痫儿童和青少年近期发作是否与更差的 HRQOL 相关。我们使用儿童健康问卷（CHQ），一种具有儿童和家长代理版本的通用量表，来衡量 HRQOL。在诊断后 9 年评估的 277 名癫痫患儿（CWE）中，与过去 1 年无发作的患儿相比，过去 1 年有发作的患儿的家长代理报告的但不是儿童自我报告的 HRQOL 在大多数量表上都明显更差。在缓解 1-5 年和缓解 5 年以上的 CWE 之间，除了父母情绪影响量表外，儿童和父母代理报告的 HRQOL 没有差异，这表明与发作近期性相关的 HRQOL 差异在缓解的最初 1 年后趋于稳定。
