Centro de Cirugía Oftalmológica (CECOF), Av. Francisco de Miranda, Torre Cavendes, Piso 6, Ofic. 6-04 Altamira, Caracas, Venezuela.
Oncol Rep. 2012 Mar;27(3):603-7. doi: 10.3892/or.2011.1563. Epub 2011 Nov 28.
Choroidal metastasis represents the most common form of intraocular malignancies. It may occur in up to 10% of patients with systemic metastasis with almost half of the patients developing central nervous system disease. The most common primary sites of ocular metastasis are breast cancer in women and lung cancer in men. In most cases, these lesions tend to be asymptomatic and are not evaluated by an ophthalmologist. The diagnosis is generally made by the history of present or prior malignancies and an ophthalmological examination with slit-lamp biomicroscopy and indirect ophthalmoscopy. As with other malignancies, management may vary with each patient. Small tumors, that do not compromise the vision and that have responded previously to systemic treatment, may be closely observed. For larger lesions and for symptomatic ones, external beam radiation offers an excellent alternative to save the eye and stabilize vision. Bevacizumab (Avastin), a potent monoclonal antibody that has also been employed for the treatment of ocular vaso-proliferative diseases, has been used in the treatment of choroidal metastasis and has shown promising results.
脉络膜转移是最常见的眼内恶性肿瘤形式。它可能发生在多达 10%的全身转移患者中，几乎一半的患者有中枢神经系统疾病。眼部转移的最常见原发性部位是女性的乳腺癌和男性的肺癌。在大多数情况下，这些病变往往是无症状的，不会被眼科医生评估。诊断通常通过目前或先前恶性肿瘤的病史以及裂隙灯生物显微镜和间接检眼镜检查得出。与其他恶性肿瘤一样，每个患者的治疗方法可能不同。对于不影响视力且先前对全身治疗有反应的小肿瘤，可以密切观察。对于较大的病变和有症状的病变，外照射放疗是一种很好的选择，可以挽救眼睛并稳定视力。贝伐单抗（阿瓦斯汀）是一种有效的单克隆抗体，也被用于治疗眼部血管增生性疾病，已被用于治疗脉络膜转移，并显示出有希望的结果。
