School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, China.
Nucleic Acids Res. 2012 Jan;40(Database issue):D1041-6. doi: 10.1093/nar/gkr1142. Epub 2011 Dec 1.
Viral integration plays an important role in the development of malignant diseases. Viruses differ in preferred integration site and flanking sequence. Viral integration sites (VIS) have been found next to oncogenes and common fragile sites. Understanding the typical DNA features near VIS is useful for the identification of potential oncogenes, prediction of malignant disease development and assessing the probability of malignant transformation in gene therapy. Therefore, we have built a database of human disease-related VIS (Dr.VIS, http://www.scbit.org/dbmi/drvis) to collect and maintain human disease-related VIS data, including characteristics of the malignant disease, chromosome region, genomic position and viral-host junction sequence. The current build of Dr.VIS covers about 600 natural VIS of 5 oncogenic viruses representing 11 diseases. Among them, about 200 VIS have viral-host junction sequence.
病毒整合在恶性疾病的发展中起着重要作用。病毒在偏好的整合位点和侧翼序列上存在差异。病毒整合位点 (VIS) 已在癌基因和常见脆性位点附近被发现。了解 VIS 附近的典型 DNA 特征对于鉴定潜在的癌基因、预测恶性疾病的发展以及评估基因治疗中恶性转化的可能性非常有用。因此，我们构建了一个人类疾病相关 VIS 的数据库 (Dr.VIS，http://www.scbit.org/dbmi/drvis)，以收集和维护人类疾病相关 VIS 数据，包括恶性疾病的特征、染色体区域、基因组位置和病毒-宿主连接序列。目前的 Dr.VIS 版本涵盖了代表 11 种疾病的 5 种致癌病毒的约 600 个天然 VIS。其中，约 200 个 VIS 具有病毒-宿主连接序列。
