James L, Gordon E, Kraiuhin C, Howson A, Meares R
Department of Psychiatry, Westmead Hospital, NSW, Australia.
J Psychiatr Res. 1990;24(2):155-63. doi: 10.1016/0022-3956(90)90055-u.
Sensory input regulation was examined in terms of augmenting/reducing of auditory evoked potentials in 10 patients with somatization disorder (8 males and 2 females) and 10 age- and sex-matched normal controls. The slope of P1-N1 amplitude change as a function of stimulus intensity was greater in patients compared with controls, suggesting an enhanced central nervous system response to sensory input. Taken together with previous findings of a failure to habituate to incoming stimuli in a similar group of patients, and evidence obtained in somatizers of both over-responding to background stimuli in a simple tone-discrimination task and enhanced parietal activation during selective attention, this finding suggests disturbances in the processes of attention and in the regulation of afferent stimuli in somatization disorder, and may help explain the multiple and chronic complaints characteristic of patients with the disorder.
