Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States.
Bioorg Med Chem. 2011 Jan 1;19(1):422-8. doi: 10.1016/j.bmc.2010.11.021. Epub 2010 Nov 11.
Investigation of the endemic Madagascar plant Leptadenia madagascariensis Decne. (Apocynaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the four new cardenolides 1-4. The structure elucidations of these compounds were based on analyzes of their 1D and 2D NMR spectra and mass spectrometric data. The cardenolides were strongly antiproliferative to the A2780 ovarian cancer cell line, with IC(50) values of 0.18, 0.21, 0.17, and 0.29μM line, and to the H460 human lung cancer cell line, with IC(50) values of 0.16, 0.68, 0.37, and 0.48μM, respectively.
对马达加斯加地方性植物 Leptadenia madagascariensis Decne.（夹竹桃科）进行抗增殖活性的研究，以寻找对 A2780 卵巢癌细胞系具有抑制作用的物质，结果分离得到了四个新的强心苷 1-4。这些化合物的结构通过对其 1D 和 2D NMR 谱和质谱数据的分析得到阐明。强心苷对 A2780 卵巢癌细胞系和 H460 人肺癌细胞系的增殖均具有强烈的抑制作用，IC50 值分别为 0.18、0.21、0.17 和 0.29μM 以及 0.16、0.68、0.37 和 0.48μM。
