Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan.
Cardiovasc Ther. 2012 Dec;30(6):301-7. doi: 10.1111/j.1755-5922.2011.00303.x. Epub 2011 Dec 5.
Macrolide antibiotics are broadly used for the treatment of various microbial infections. However, they are also known to have multiple biologic effects, such as alteration of inflammatory factors and matrix metalloproteinases (MMPs). Because of controversial results in clinical trials, the effects of macrolides on cardiovascular diseases are still to be elucidated. It has been reported that MMP activity is upregulated in various cardiovascular diseases, such as myocarditis, cardiac transplant rejection and myocardial infarction. However, little is known about the effects of macrolides on cardiovascular diseases. We have reported that clarithromycin suppressed the development of myocarditis, cardiac rejection and myocardial ischemia using animal models. In this article, we reviewed the roles of MMPs in cardiovascular diseases and the effects of macrolides on the prevention of adverse tissue remodeling.
大环内酯类抗生素被广泛用于治疗各种微生物感染。然而，它们也具有多种生物学效应，如改变炎症因子和基质金属蛋白酶（MMPs）。由于临床试验的结果存在争议，大环内酯类药物对心血管疾病的影响仍有待阐明。据报道，MMP 活性在各种心血管疾病中上调，如心肌炎、心脏移植排斥和心肌梗死。然而，关于大环内酯类药物对心血管疾病的影响知之甚少。我们已经报道了克拉霉素通过动物模型抑制心肌炎、心脏排斥和心肌缺血的发展。在本文中，我们综述了 MMPs 在心血管疾病中的作用以及大环内酯类药物在预防不良组织重构中的作用。
