Hollis J F, Connett J E, Stevens V J, Greenlick M R
Kaiser Permanente Center for Health Research, Portland, Oregon 97215.
J Behav Med. 1990 Jun;13(3):263-80. doi: 10.1007/BF00846834.
The relationship between stressful life events and subsequent mortality and morbidity were determined prospectively over 6 years for 12,866 men participating in the Multiple Risk Factor Intervention Trial (MRFIT). Aslo evaluated was the impact of life events on cardiovascular outcomes for persons exhibiting and not exhibiting coronary prone (Type A) behavior. Subjects completed life events checklists at baseline and each of five annual visits. Participants were also administered the Jenkins Activity Survey measure of Type A behavior at baseline and a subsample of 3110 participants was categorized as to behavior type based on the structured interview assessment method. Cox proportional hazard analyses indicated that number of life events experienced during each of 6 years of follow-up was unrelated to risk in the subsequent year of CHD death or fatal plus nonfatal MI and was inversely related to total mortality. The impact of life events on cardiovascular risk did not differ by behavior type category.
在一项针对12866名参与多重危险因素干预试验（MRFIT）的男性进行的前瞻性研究中，对紧张性生活事件与随后的死亡率和发病率之间的关系进行了为期6年的测定。同时还评估了生活事件对表现出和未表现出冠心病倾向（A型）行为的人群心血管结局的影响。受试者在基线以及每年的五次随访中均完成生活事件清单。参与者在基线时还接受了A型行为的詹金斯活动调查测量，并且根据结构化访谈评估方法，对3110名参与者的子样本进行了行为类型分类。Cox比例风险分析表明，在6年随访期间每年经历的生活事件数量与次年冠心病死亡风险或致命加非致命心肌梗死风险无关，且与总死亡率呈负相关。生活事件对心血管风险的影响在行为类型类别之间没有差异。
