Department of Health Outcomes and Biomedical Informatics, University of Florida, PO Box 100177, Gainesville, FL, 32610-0177, USA.
Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA.
Psychoneuroendocrinology. 2018 Apr;90:141-147. doi: 10.1016/j.psyneuen.2018.02.014. Epub 2018 Feb 20.
Using Jackson Heart Study (JHS) data, we assessed the association between perceived psychosocial stressors and metabolic syndrome (MetS) severity in African American adults.
Participants included 3870 African American JHS participants aged 21-95 years (63.1% women; mean age 53.8 ± 13.0). Psychosocial stressors assessed included: major life events (MLEs); global stress; and weekly stress inventory. Each stress measure was classified into tertiles (low, medium, and high). Associations of psychosocial stressors with a sex- and race/ethnic-specific MetS severity Z-score were examined after adjustment for demographics and MetS risk factors (i.e., nutrition, physical activity, smoking status, and alcohol consumption).
Independent of lifestyle factors, participants who reported high (versus low) perceived global stress and MLEs had significantly greater MetS severity (p = .0207 and p = .0105, respectively). Weekly stress was not associated with MetS severity. Compared to men, women reported significantly higher global stress and MLEs (p < 0.0001). A significant interaction between sex and MLEs (p = .0456) demonstrated men significantly increased their MetS severity at medium levels of stress, whereas women's MetS severity was significantly increased at high levels of MLEs.
In the total sample, higher reported global stress and MLEs were associated with increased risk of MetS severity, while weekly stress was not. Men's and women's stress responses to MLEs were differentially associated with MetS severity, with male MetS severity increasing significantly at lower levels of MLEs relative to women's MetS severity. These data may have implications for targeting stress-related factors in interventions to improve cardiometabolic health in African American adults.
利用杰克逊心脏研究（JHS）的数据，我们评估了非裔美国成年人感知到的心理社会压力源与代谢综合征（MetS）严重程度之间的关系。
参与者包括 3870 名年龄在 21-95 岁的非裔美国 JHS 参与者（63.1%为女性；平均年龄 53.8±13.0 岁）。评估的心理社会压力源包括：重大生活事件（MLEs）；总体压力；和每周压力量表。每个压力测量值被分为三分位（低、中、高）。在调整了人口统计学和 MetS 危险因素（即营养、身体活动、吸烟状况和饮酒）后，检查了心理社会压力源与性别和种族/民族特异性 MetS 严重程度 Z 评分之间的关联。
独立于生活方式因素，报告高（而非低）感知到的总体压力和 MLE 的参与者的 MetS 严重程度显著更高（p=0.0207 和 p=0.0105，分别）。每周压力与 MetS 严重程度无关。与男性相比，女性报告的总体压力和 MLE 明显更高（p<0.0001）。性别与 MLE 之间存在显著的交互作用（p=0.0456），表明男性在中等压力水平下，MetS 严重程度显著增加，而女性在 MLE 水平较高时，MetS 严重程度显著增加。
在总样本中，较高的报告全球压力和 MLE 与 MetS 严重程度的增加风险相关，而每周压力则没有。男性和女性对 MLE 的应激反应与 MetS 严重程度的相关性不同，与女性相比，男性的 MetS 严重程度在较低的 MLE 水平下显著增加。这些数据可能对针对非裔美国成年人干预措施中与压力相关的因素具有重要意义，以改善其心脏代谢健康。
