Gump B B, Matthews K A
Department of Psychology, State University of New York, Oswego 13126, USA.
Psychosom Med. 2000 Sep-Oct;62(5):608-12. doi: 10.1097/00006842-200009000-00003.
The objective of this study was to determine the risk for various causes of posttrial death associated with vacation frequency during the Multiple Risk Factor Intervention Trial (MRFIT).
Middle-aged men at high risk for coronary heart disease (CHD) were recruited for the MRFIT. As part of the questionnaires administered during the first five annual visits, men were asked whether they had had a vacation during the past year. For trial survivors (N = 12,338), the frequency of these annual vacations during the trial were used in a prospective analysis of posttrial all-cause and cause-specific mortality during the 9-year follow-up period.
The relative risk (RR) associated with more annual vacations during the trial was 0.83 (95% confidence interval [CI], 0.71-0.97) for all-cause mortality during the 9-year follow-up period. For cause of death, the RRs were 0.71 (95% CI, 0.58-0.89) and 0.98 (95% CI, 0.78-1.23) for cardiovascular and noncardiovascular causes, respectively. The RR was 0.68 (95% CI, 0.53-0.88) for CHD (including acute myocardial infarction). These associations remained when statistical adjustments were made for possible confounding variables, including baseline characteristics (eg, income), MRFIT group assignment, and occurrence of a nonfatal cardiovascular event during the trial.
The frequency of annual vacations by middle-aged men at high risk for CHD is associated with a reduced risk of all-cause mortality and, more specifically, mortality attributed to CHD. Vacationing may be good for your health.
本研究的目的是确定在多重危险因素干预试验（MRFIT）期间，与休假频率相关的试验后各种死因的风险。
招募有冠心病（CHD）高风险的中年男性参与MRFIT。作为前五次年度访视期间所发放问卷的一部分，男性被问及过去一年是否休过假。对于试验幸存者（N = 12,338），在9年随访期内，将试验期间这些年度休假的频率用于对试验后全因死亡率和特定原因死亡率的前瞻性分析。
在9年随访期内，试验期间年度休假较多的相对风险（RR）对于全因死亡率为0.83（95%置信区间[CI]，0.71 - 0.97）。对于死因，心血管原因和非心血管原因的RR分别为0.71（95% CI，0.58 - 0.89）和0.98（95% CI，0.78 - 1.23）。冠心病（包括急性心肌梗死）的RR为0.68（95% CI，0.53 - 0.88）。在对可能的混杂变量进行统计调整后，这些关联仍然存在，这些混杂变量包括基线特征（如收入）、MRFIT组分配以及试验期间非致命心血管事件的发生情况。
有CHD高风险的中年男性的年度休假频率与全因死亡率降低相关，更具体地说，与归因于CHD的死亡率降低相关。休假可能有益健康。
