Departments of Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Clin Cancer Res. 2012 Jan 15;18(2):323-5. doi: 10.1158/1078-0432.CCR-11-2870. Epub 2011 Dec 2.
Driving cancer cells into a more differentiated state is a rational therapeutic approach. Primary uveal melanoma cells with a propensity to metastasize have less-differentiated features than their less aggressive counterparts. Treatment of uveal melanoma cells with histone deacetylase inhibitors induces a more differentiated phenotype with resultant lower growth capacity.
促使癌细胞向更分化的状态发展是一种合理的治疗方法。具有转移倾向的原发性葡萄膜黑色素瘤细胞比侵袭性较低的细胞具有较少分化的特征。组蛋白去乙酰化酶抑制剂治疗葡萄膜黑色素瘤细胞可诱导出更分化的表型，从而降低生长能力。
