• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

豚鼠新型内源性疱疹病毒：生物学及分子特征

New endogenous herpesvirus of guinea pigs: biological and molecular characterization.

作者信息

Bia F J, Summers W C, Fong C K, Hsiung G D

出版信息

J Virol. 1980 Oct;36(1):245-53. doi: 10.1128/JVI.36.1.245-253.1980.

DOI:10.1128/JVI.36.1.245-253.1980
PMID:6255209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC353635/
Abstract

Two known guinea pig herpesviruses, guinea pig cytomegalovirus (GPCMV) and guinea pig herpes-like virus (GPHLV), and well characterized. A third herpesvirus (GPXV) was originally isolated from leukocytes of healthy strain 2 guinea pigs. Growth of GPXV in guinea pig embryo fibroblastic cells produced a characteristic cytopathic effect. Electron microscopy of guinea pig cells infected with GPXV revealed the morphological development of a herpesvirus. Cross-neutralization tests and immunoferritin electron microscopy demonstrated that GPXV, GPCMV, and GPHLV were serologically distinct herpeviruses of guinea pigs. To confirm the distinction between these three herpesviruses, DNA genomes were compared by CsCl equilibrium buoyant density measurements and restriction endonuclease cleavage analysis. 32P-labeled viral DNA ws obtained from nucleocapsids isolated from virus-infected cells, and the buoyant density of GPXV DNA differed from that of GPCMV and GPHLV. Cleavage of viral DNAs with restriction endonucleases followed by gel electrophoresis revealed distinct patterns for each virus.

摘要

两种已知的豚鼠疱疹病毒，即豚鼠巨细胞病毒（GPCMV）和豚鼠类疱疹病毒（GPHLV），已得到充分表征。第三种疱疹病毒（GPXV）最初是从健康的2系豚鼠的白细胞中分离出来的。GPXV在豚鼠胚胎成纤维细胞中的生长产生了特征性的细胞病变效应。对感染GPXV的豚鼠细胞进行电子显微镜检查，揭示了一种疱疹病毒的形态发育过程。交叉中和试验和免疫铁蛋白电子显微镜检查表明，GPXV、GPCMV和GPHLV是豚鼠血清学上不同的疱疹病毒。为了证实这三种疱疹病毒之间的区别，通过氯化铯平衡浮力密度测量和限制性内切酶切割分析对DNA基因组进行了比较。从病毒感染细胞中分离的核衣壳中获得了32P标记的病毒DNA，并且GPXV DNA的浮力密度与GPCMV和GPHLV的不同。用限制性内切酶切割病毒DNA，然后进行凝胶电泳，揭示了每种病毒的独特模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/30cdacbbb48e/jvirol00178-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/1e002c2966df/jvirol00178-0257-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/8146ec5a88c2/jvirol00178-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/b4ed1d185d84/jvirol00178-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/24fe970ffdcf/jvirol00178-0260-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/30cdacbbb48e/jvirol00178-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/1e002c2966df/jvirol00178-0257-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/8146ec5a88c2/jvirol00178-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/b4ed1d185d84/jvirol00178-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/24fe970ffdcf/jvirol00178-0260-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5a/353635/30cdacbbb48e/jvirol00178-0261-a.jpg

相似文献

1
New endogenous herpesvirus of guinea pigs: biological and molecular characterization.豚鼠新型内源性疱疹病毒：生物学及分子特征
J Virol. 1980 Oct;36(1):245-53. doi: 10.1128/JVI.36.1.245-253.1980.
2
Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: growth characteristics and antigentic relationship.豚鼠巨细胞病毒与豚鼠类疱疹病毒的比较：生长特性及抗原关系
Infect Immun. 1976 Mar;13(3):926-33. doi: 10.1128/iai.13.3.926-933.1976.
3
Characterization of guinea pig cytomegalovirus DNA.豚鼠巨细胞病毒DNA的特性分析。
J Virol. 1984 Feb;49(2):426-36. doi: 10.1128/JVI.49.2.426-436.1984.
4
Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: pathogenesis and persistence in experimentally infected animals.豚鼠巨细胞病毒与豚鼠类疱疹病毒的比较：实验感染动物中的发病机制与持续性
Infect Immun. 1976 Mar;13(3):934-40. doi: 10.1128/iai.13.3.934-940.1976.
5
Isolation and characterization of a herpesvirus from leukemic guinea pigs.从患白血病的豚鼠中分离并鉴定一种疱疹病毒。
J Virol. 1971 Oct;8(4):579-88. doi: 10.1128/JVI.8.4.579-588.1971.
6
Guinea pig herpes like virus is a gamma herpesvirus.豚鼠疱疹样病毒是一种γ疱疹病毒。
Virus Genes. 2024 Apr;60(2):148-158. doi: 10.1007/s11262-024-02054-x. Epub 2024 Feb 10.
7
A latent guinea pig herpes-like virus: isolation and envelopment.一种潜伏性豚鼠疱疹样病毒：分离与包膜化
J Gen Virol. 1975 Aug;28(2):199-206. doi: 10.1099/0022-1317-28-2-199.
8
Induction of tumors by a guinea pig herpesvirus-transformed hamster cell line.豚鼠疱疹病毒转化的仓鼠细胞系诱发肿瘤
J Natl Cancer Inst. 1976 Jun;56(6):1165-70. doi: 10.1093/jnci/56.6.1165.
9
Comparative studies on Marek's disease virus and herpesvirus of turkey DNAs.马立克氏病病毒与火鸡疱疹病毒DNA的比较研究。
J Gen Virol. 1979 Oct;45(1):119-31. doi: 10.1099/0022-1317-45-1-119.
10
Expression of herpesvirus in adherent cells derived from bone marrow of latently infected guinea pigs.潜伏感染豚鼠骨髓来源的贴壁细胞中疱疹病毒的表达
Am J Pathol. 1978 Jun;91(3):483-96.

引用本文的文献

1
Guinea Pig X Virus Is a Gammaherpesvirus.豚鼠X病毒是一种γ疱疹病毒。
Viruses. 2025 Aug 5;17(8):1084. doi: 10.3390/v17081084.
2
Guinea pig herpes like virus is a gamma herpesvirus.豚鼠疱疹样病毒是一种γ疱疹病毒。
Virus Genes. 2024 Apr;60(2):148-158. doi: 10.1007/s11262-024-02054-x. Epub 2024 Feb 10.
3
A neutralizing anti-gH/gL monoclonal antibody is protective in the guinea pig model of congenital CMV infection.一种中和性抗gH/gL单克隆抗体在先天性巨细胞病毒感染的豚鼠模型中具有保护作用。

本文引用的文献

1
Serial propagation of the guinea pig salivary gland virus in tissue culture.豚鼠唾液腺病毒在组织培养中的连续传代
Proc Soc Exp Biol Med. 1957 Nov;96(2):281-5. doi: 10.3181/00379727-96-23455.
2
Molecular epidemiology of DNA viruses: applications of restriction endonuclease cleavage site analysis.DNA病毒的分子流行病学：限制性内切酶切割位点分析的应用
Yale J Biol Med. 1980 Jan-Feb;53(1):55-9.
3
Herpeslike virus isolated from spontaneously degenerated tissue culture derived from leukemia-susceptible guinea pigs.从白血病易感豚鼠自发退化的组织培养物中分离出的疱疹样病毒。
PLoS Pathog. 2014 Apr 10;10(4):e1004060. doi: 10.1371/journal.ppat.1004060. eCollection 2014 Apr.
4
Guinea Pig Cytomegalovirus (GPCMV): A Model for the Study of the Prevention and Treatment of Maternal-Fetal Transmission.豚鼠巨细胞病毒（GPCMV）：母婴传播预防与治疗研究的模型
Future Virol. 2010 Mar;5(2):207-217. doi: 10.2217/fvl.10.8.
5
Characterization of guinea pig cytomegalovirus DNA.豚鼠巨细胞病毒DNA的特性分析。
J Virol. 1984 Feb;49(2):426-36. doi: 10.1128/JVI.49.2.426-436.1984.
6
Filamentous structures associated with Epstein-Barr virus-infected cells.与爱泼斯坦-巴尔病毒感染细胞相关的丝状结构。
J Virol. 1982 Jul;43(1):305-13. doi: 10.1128/JVI.43.1.305-313.1982.
7
Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia.实验性巨细胞病毒性间质性肺炎期间的肺巨噬细胞功能
Infect Immun. 1985 Jan;47(1):211-6. doi: 10.1128/iai.47.1.211-216.1985.
8
Animal cytomegaloviruses.动物巨细胞病毒
Microbiol Rev. 1990 Sep;54(3):247-65. doi: 10.1128/mr.54.3.247-265.1990.
9
The family Herpesviridae: an update. The Herpesvirus Study Group of the International Committee on Taxonomy of Viruses.疱疹病毒科：最新进展。国际病毒分类委员会疱疹病毒研究小组。
Arch Virol. 1992;123(3-4):425-49. doi: 10.1007/BF01317276.
J Virol. 1969 Mar;3(3):355-7. doi: 10.1128/JVI.3.3.355-357.1969.
4
Ultrastructural studies of the envelopment and release of guinea pig herpes-like virus in cultured cells.豚鼠疱疹样病毒在培养细胞中的包被与释放的超微结构研究。
Virology. 1973 Apr;52(2):468-77. doi: 10.1016/0042-6822(73)90342-5.
5
The growth of varicella-zoster virus in guinea pig embryo cells.水痘-带状疱疹病毒在豚鼠胚胎细胞中的生长
Proc Soc Exp Biol Med. 1973 Oct 1;144(1):340-4. doi: 10.3181/00379727-144-37587.
6
Herpesvirus infection of guinea pigs. I. Isolation, characterization and pathogenicity.豚鼠的疱疹病毒感染。I. 分离、鉴定及致病性。
Am J Epidemiol. 1971 Apr;93(4):298-307. doi: 10.1093/oxfordjournals.aje.a121261.
7
Classification and nomenclature of viruses. Second report of the International Committee on Taxonomy of Viruses.病毒的分类与命名。国际病毒分类委员会第二次报告。
Intervirology. 1976;7(1-2):1-115. doi: 10.1159/000149938.
8
Cytomegalovirus infection in guinea pigs. III. Persistent viruria, blood transmission, and viral interference.
J Infect Dis. 1979 Dec;140(6):914-20. doi: 10.1093/infdis/140.6.914.
9
Guinea pig cytomegalovirus: transplacental transmission. Brief report.
Arch Virol. 1979;59(3):263-7. doi: 10.1007/BF01317422.
10
Ultrastructural development of guinea pig cytomegalovirus in cultured guinea pig embryo cells.豚鼠巨细胞病毒在培养的豚鼠胚胎细胞中的超微结构发育
J Gen Virol. 1979 Jan;42(1):127-40. doi: 10.1099/0022-1317-42-1-127.