Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, China.
Langmuir. 2012 Jan 31;28(4):2083-90. doi: 10.1021/la203518w. Epub 2011 Dec 13.
Three flexible peptides (P1: (C(17)H(35)CO-NH-GRGDG)(2)KG; P2: (Fmoc-GRGDG)(2)KG; P3: (CH(3)CO-NH-GRGDG)(2)KG) self-assembled to form a variety of morphologically distinct assemblies at different pHs. P1 formed nanofibers at pH 3, then self-assembled into nanospheres with pH up to 6 and further changed to lamellar structures when the pH value was further increased to 10. P2 aggregated into an entwined network structure at pH 3, and then self-assembled into well-defined nanospheres, lamellar structures, and vesicles via adjusting the pH value. However, P3 did not self-assemble into well-ordered nanostructures, presumably due to the absence of a large hydrophobic group. The varying self-assembly behaviors of the peptides at different pHs are attributed to molecular conformational changes. These self-assembled supramolecular materials might contribute to the development of new peptide-based biomaterials.
三种柔性多肽（P1：（C(17)H(35)CO-NH-GRGDG)(2)KG；P2：（Fmoc-GRGDG)(2)KG；P3：（CH(3)CO-NH-GRGDG)(2)KG））在不同 pH 值下自组装形成各种形态不同的组装体。P1 在 pH 3 时形成纳米纤维，然后在 pH 上升至 6 时自组装成纳米球，并在 pH 值进一步增加到 10 时进一步转变为层状结构。P2 在 pH 3 时聚集形成纠结的网络结构，然后通过调节 pH 值自组装成规则的纳米球、层状结构和囊泡。然而，P3 并没有自组装成有序的纳米结构，可能是因为缺少大的疏水基团。多肽在不同 pH 值下的变化自组装行为归因于分子构象的变化。这些自组装的超分子材料可能有助于开发新型基于肽的生物材料。
