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用于靶向癌细胞成像的新型寡肽纳米探针。

Novel oligopeptide nanoprobe for targeted cancer cell imaging.

作者信息

Ding Wen-Qiang, Qin Si-Yong, Cheng Yin-Jia, Ma Yi-Han, Zhang Ai-Qing

机构信息

College of Chemistry and Materials Science, South-Central University for Nationalities Wuhan 430074 P. R. China

出版信息

RSC Adv. 2018 Sep 3;8(54):30887-30893. doi: 10.1039/c8ra06034g. eCollection 2018 Aug 30.

DOI:10.1039/c8ra06034g
PMID:35548769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9085486/
Abstract

Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π-π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells.

摘要

在此，我们设计并构建了一种色氨酸-苯丙氨酸-苯丙氨酸-色氨酸（WFFW）四肽，其可产生从340纳米至500纳米的光稳定且可调谐的荧光发射信号。WFFW四肽能够自组装成具有增强荧光强度的球形纳米结构。在π-π堆积和氢键相互作用的驱动下，WFFW与精氨酸-甘氨酸-天冬氨酸（RGD）修饰的WFFW共组装，形成一种癌症靶向荧光纳米探针，该探针能够选择性地对癌细胞进行成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/273b4b4440ee/c8ra06034g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/bb7d791b26e7/c8ra06034g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/67a73572af45/c8ra06034g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/f7a7ebd76228/c8ra06034g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/a34396671adb/c8ra06034g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/1d259e2bd8f2/c8ra06034g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/273b4b4440ee/c8ra06034g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/bb7d791b26e7/c8ra06034g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/67a73572af45/c8ra06034g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/f7a7ebd76228/c8ra06034g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/a34396671adb/c8ra06034g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/1d259e2bd8f2/c8ra06034g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e5e/9085486/273b4b4440ee/c8ra06034g-f6.jpg

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本文引用的文献

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