Richards D W, Janesick J R, Elliot S T, Dingizian A, Velthuizen R, Wei Q, Clarke L P
Department of Ophthalmology, University of South Florida College of Medicine, Tampa.
Graefes Arch Clin Exp Ophthalmol. 1993 Oct;231(10):595-9. doi: 10.1007/BF00936525.
We used a 1024 x 1024 pixel, 15-microns, 16-bit-encoding, multi-pin-phase charge-coupled device (CCD) to obtain images of the normal human retinal nerve fiber layer. This device, which operates at room temperature, offers significantly better signal-to-noise ratio, linearity, and dynamic range than do photographic film, video imaging techniques, or commercially available CCDs. We demonstrate the use of a nonlinear digital filter, together with filter windows, that enhances fine detail of NFL striations, while suppressing noise, in limited areas of the CCD images. High-sensitivity imaging of this type, together with appropriate digital processing, may prove useful in diagnosing and following nerve-fiber-layer damage due to glaucoma.
我们使用了一台1024×1024像素、15微米、16位编码的多针相电荷耦合器件（CCD）来获取正常人类视网膜神经纤维层的图像。该设备在室温下运行，与摄影胶片、视频成像技术或市售CCD相比，具有显著更好的信噪比、线性度和动态范围。我们展示了一种非线性数字滤波器与滤波窗口的结合使用，它能在CCD图像的有限区域内增强神经纤维层条纹的精细细节，同时抑制噪声。这种高灵敏度成像与适当的数字处理相结合，可能在青光眼导致的神经纤维层损伤的诊断和随访中发挥作用。
