一项比较三种牙本质敏感症治疗方法的双盲对照试验。
A double blind controlled trial comparing three treatment modalities for dentin hypersensitivity.
机构信息
Department of Periodontology, Government Dental College and Hospital Ahmedabad, Gujarat.
出版信息
Med Oral Patol Oral Cir Bucal. 2012 May 1;17(3):e483-90. doi: 10.4317/medoral.17594.
AIM
This randomized, double blind, split mouth study was aimed to compare three dentin desensitizing treatment modalities.
METHODS
Two hundred sixty teeth of 25 patients; each having at least 2 hypersensitive teeth in each quadrant, were included. Teeth were randomized to 4 groups: Group A treated with 2% NaF solution, Group B received GLUMA®; an aqueous solution of Hydroxy-Ethyl-Methacrylate and Glutarldehyde, (HEMA-G), Group C received iontophoresis with distilled water (placebo) and Group D was treated with NaF-iontophoresis. Pain response was evaluated on a visual analogue scale (VAS), by using tactile, air blast and cold-water stimuli at 0-day, 15-day, 1-month and 3-months interval.
RESULTS
All treatments were effective in reducing dentinal hypersensitivity significantly, Group D and Group B were more effective than Group A and Group C at all time intervals. Group D and Group B were equally effective in reducing dentinal hypersensitivity at 15-day and 1-month interval but Group D was more effective at 3-months.
CONCLUSION
All treatment modalities were more effective in reducing hypersensitivity than placebo. 2% NaF-iontophoresis and HEMA-G were more effective than 2% NaF local application at all time intervals. But at 3-months, 2% NaF-iontophoresis was more effective than HEMA-G, while placebo produced no significant effect in reduction of hypersensitivity.
目的
本随机、双盲、分口研究旨在比较三种牙本质脱敏治疗方法。
方法
纳入 25 名患者的 260 颗牙齿；每个象限至少有 2 颗敏感牙。将牙齿随机分为 4 组：A 组用 2%氟化钠溶液处理，B 组用 GLUMA®处理，即羟乙基甲基丙烯酸酯和戊二醛的水溶液（HEMA-G），C 组用蒸馏水进行离子导入（安慰剂），D 组用氟化钠离子导入处理。使用视觉模拟量表（VAS）评估疼痛反应，通过触觉、空气喷吹和冷水刺激在 0 天、15 天、1 个月和 3 个月时进行评估。
结果
所有治疗方法均能显著降低牙本质敏感性，D 组和 B 组在所有时间间隔均比 A 组和 C 组更有效。D 组和 B 组在 15 天和 1 个月时同样有效降低牙本质敏感性，但 D 组在 3 个月时更有效。
结论
与安慰剂相比，所有治疗方法均能更有效地降低敏感性。2%氟化钠离子导入和 HEMA-G 在所有时间间隔均比 2%氟化钠局部应用更有效。但在 3 个月时，2%氟化钠离子导入比 HEMA-G 更有效，而安慰剂在降低敏感性方面没有显著效果。
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