Aydemir O, Akar M, Uras N, Eras Z, Erdeve O, Oguz S S, Dilmen U
Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
Neuropediatrics. 2011 Dec;42(6):222-6. doi: 10.1055/s-0031-1295480. Epub 2011 Dec 5.
This study aimed to investigate the global oxidant/antioxidant status of infants with perinatal asphyxia and its relation to neurological outcomes. A prospective controlled study including term infants with perinatal asphyxia was conducted. Blood samples were obtained from patients and controls at 6-24 h and on the 3rd day of life for TAC and TOS measurement and OSI values were calculated. Neurodevelopment was evaluated at 12 months of age in survivors using Bayley scales of infant development II (BSID II). 17 term infants with perinatal asphyxia and 17 healthy controls were enrolled. On the first day of life TAC, TOS and OSI were significantly higher in patients with perinatal asphyxia (p<0.001). Total antioxidant capacity decreased significantly on day 3 compared to first day of life in the patient group (p=0.04). Infants with seizures and abnormal amplitude-integrated electroencephalography recordings had higher TOS and OSI levels in the 1st day. There was no correlation between TAC, TOS and OSI levels and BSID II scores. In conclusion oxidant/antioxidant balance is disturbed in favour of oxidants in perinatal asphyxia. Degree of oxidative stress is related to severity of neurological involvement in the first days of life.
本研究旨在调查围产期窒息婴儿的整体氧化/抗氧化状态及其与神经学结局的关系。开展了一项前瞻性对照研究，纳入足月围产期窒息婴儿。在出生后6 - 24小时以及出生第3天采集患者和对照组的血样，用于测量总抗氧化能力（TAC）和总氧化应激（TOS），并计算氧化应激指数（OSI）值。使用贝利婴儿发育量表第二版（BSID II）在12月龄时对存活者的神经发育进行评估。纳入了17例足月围产期窒息婴儿和17例健康对照。在出生第一天，围产期窒息患者的TAC、TOS和OSI显著更高（p<0.001）。与出生第一天相比，患者组在第3天总抗氧化能力显著下降（p = 0.04）。有癫痫发作和振幅整合脑电图记录异常的婴儿在出生第一天TOS和OSI水平更高。TAC、TOS和OSI水平与BSID II评分之间无相关性。总之，围产期窒息时氧化/抗氧化平衡向氧化剂方向失调。氧化应激程度与出生后最初几天神经受累的严重程度相关。
