Department of Food Science and Biotechnology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan.
J Sci Food Agric. 2012 May;92(7):1483-9. doi: 10.1002/jsfa.4731. Epub 2011 Dec 5.
Monascus-fermented products have featured in Chinese cuisine for thousands of years and are widely used as food colourants and dietary materials in many Asian countries. Rice and dioscorea fermented with Monascus purpureus NTU 568 have health-promoting attributes in vitro and in vivo. The aim of this study was to investigate the immunomodulatory and antioxidant effects of polysaccharides from red mould rice (RMRP) and red mould dioscorea (RMDP) in Raw 264.7 cells.
The results showed the antioxidant capabilities (including scavenging, chelating, inhibition of lipid peroxidation, and reducing power) of RMRP and RMDP at a concentration of 10 mg mL(-1). RMRP and RMDP also stimulated cell proliferation, nitric oxide production, phagocytosis and cytokine production (including IL1-β, IL-6 and TNF-α) in Raw 264.7 cells.
These findings demonstrate that RMRP and RMDP have antioxidant and immunomodulation potential to be developed as novel dietary supplements.
红曲米在中式烹饪中已有数千年的历史，是许多亚洲国家常用的食品着色剂和膳食材料。红曲米和山药经 NTU 568 米曲菌发酵后，具有体外和体内的促进健康属性。本研究旨在探讨红曲米多糖（RMRP）和红曲山药多糖（RMDP）对 Raw 264.7 细胞的免疫调节和抗氧化作用。
结果表明，RMRP 和 RMDP 在 10mg/mL 浓度下具有抗氧化能力（包括清除、螯合、抑制脂质过氧化和还原能力）。RMRP 和 RMDP 还刺激 Raw 264.7 细胞的增殖、一氧化氮产生、吞噬作用和细胞因子产生（包括 IL1-β、IL-6 和 TNF-α）。
这些发现表明，RMRP 和 RMDP 具有抗氧化和免疫调节潜力，可开发为新型膳食补充剂。
