Domi Rudin
Department of Anesthesiology, Intensive Care, Emergency, and Toxicology, University Hospital Center "Mother Theresa", Tirana, Albania.
Indian J Endocrinol Metab. 2011 Oct;15 Suppl 4(Suppl4):S322-8. doi: 10.4103/2230-8210.86975.
Cushing's syndrome is a clinical situation, caused by excessive glucocorticoid level, resulting in several features such as central obesity, supraclavicular fat, "moon face," "buffalo hump," hyperglycemia, metabolic alkalosis, hypokalemia, poor wound healing, easy bruising, hypertension, proximal muscle weakness, thin extremities, skin thinning, menstrual irregularities, and purple striae. In the perioperative period, the anesthesiologist must deal with difficult ventilation and intubation, hemodynamic disturbances, volume overload and hypokalemia, glucose intolerance, and diabetes, maintaining the blood cortisol level and preventing the glucocorticoid deficiency. This syndrome is quite rare and its features make these patients very difficult to the anesthesiologist.
库欣综合征是一种临床病症，由糖皮质激素水平过高引起，会导致多种特征，如向心性肥胖、锁骨上脂肪堆积、“满月脸”、“水牛背”、高血糖、代谢性碱中毒、低钾血症、伤口愈合不良、易出现瘀斑、高血压、近端肌无力、四肢消瘦、皮肤变薄、月经不规律以及紫纹。在围手术期，麻醉医生必须应对通气和插管困难、血流动力学紊乱、容量超负荷和低钾血症、葡萄糖不耐受以及糖尿病等问题，维持血液皮质醇水平并预防糖皮质激素缺乏。这种综合征相当罕见，其特征使得这些患者对麻醉医生来说极具挑战性。
