Sopo S Miceli, Onesimo R, Giorgio V, Fundarò C, Tabacco F, Calvani M
Department of Pediatrics, Catholic University of Rome, Rome, Italy.
Eur Ann Allergy Clin Immunol. 2011 Oct;43(5):157-61.
Preschool children frequently suffer from acute respiratory tract infections (ARTI). Immunostimulants (ISs) are often administered to reduce their impact. This study aimed to establish the efficacy of ISs in the prevention of pediatric ARTI through the analysis of systematic reviews (SRs). We explored Medline database in October 2010 limiting our search to SRs, that included studies on the effectiveness of ISs in the prevention of pediatric ARTI. Six SRs with meta analysis (MA) were found. The studies included showed a low methodological quality and a high statistical heterogeneity. All papers published on journals with impact factor > 1 and a Jadad score > 3 reviewed the efficacy of OM-85. The number needed to treat (NNT) was between 2 and 11, depending on the setting.
Pediatric ARTI are a social and health care problem. When they impair the quality of life of the family a course of OM-85 might be warranted. Although scientific knowledge of clinicians may be improved by SRs, MA and aggregation of results may not always be the best way to accomplish this.
学龄前儿童经常患急性呼吸道感染（ARTI）。免疫刺激剂（ISs）常被用于减轻其影响。本研究旨在通过系统评价（SRs）分析来确定免疫刺激剂在预防儿童ARTI方面的疗效。我们于2010年10月检索了Medline数据库，将搜索范围限制在系统评价，这些系统评价纳入了关于免疫刺激剂预防儿童ARTI有效性的研究。共找到6篇带有荟萃分析（MA）的系统评价。纳入的研究显示方法学质量较低且存在高度统计学异质性。所有发表在影响因子>1且Jadad评分>3的期刊上的论文都对OM - 85的疗效进行了综述。根据不同情况，需治疗人数（NNT）在2至11之间。
儿童ARTI是一个社会和医疗保健问题。当它们影响家庭生活质量时，OM - 85疗程可能是必要的。尽管系统评价、荟萃分析和结果汇总可能会提高临床医生的科学知识，但这并非总是实现这一目标的最佳方式。
