Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Ann N Y Acad Sci. 2011 Dec;1239:138-48. doi: 10.1111/j.1749-6632.2011.06268.x.
Neuroscientific research has emphatically promoted the idea that the key function of the orbitofrontal cortex (OFC) is to encode value. Associative learning studies indicate that OFC representations of stimulus cues reflect the predictive value of expected outcomes. Neuroeconomic studies suggest that the OFC distills abstract representations of value from discrete commodities to optimize choice. Although value-based models provide good explanatory power for many different findings, these models are typically disconnected from the very stimuli and commodities giving rise to those value representations. Little provision is made, either theoretically or empirically, for the necessary cooperative role of object identity, without which value becomes orphaned from its source. As a step toward remediating the value of identity, this review provides a focused olfactory survey of OFC research, including new work from our lab, to highlight the elemental involvement of this region in stimulus-specific predictive coding of both perceptual outcomes and expected values.
神经科学研究强调了眶额皮层(OFC)的关键功能是对价值进行编码。联想学习研究表明,刺激线索的 OFC 代表反映了预期结果的预测价值。神经经济学研究表明,OFC 从离散商品中提取价值的抽象表示,以优化选择。尽管基于价值的模型为许多不同的发现提供了很好的解释力,但这些模型通常与产生这些价值表示的刺激和商品没有联系。无论是在理论上还是在经验上,都很少为对象身份的必要合作作用提供依据,如果没有这种合作作用,价值就会与其来源失去联系。作为纠正身份价值的一个步骤,本综述提供了对 OFC 研究的重点嗅觉调查,包括我们实验室的新工作,以强调该区域在感知结果和预期价值的刺激特异性预测编码中的基本参与。
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