眶额皮质与反应选择。
The orbitofrontal cortex and response selection.
机构信息
Mount Sinai School of Medicine, New York, New York 10029, USA.
出版信息
Ann N Y Acad Sci. 2011 Dec;1239:25-32. doi: 10.1111/j.1749-6632.2011.06279.x.
Orbitofrontal cortex (OFC) function is often characterized in terms of stimulus-reward mapping; however, more recent evidence suggests that the OFC may play a role in selecting and representing extended actions. First, previously encoded reward associations in the OFC could be used to inform responding in novel but similar situations. Second, when evaluated in tasks requiring the animal to perform extended actions, response selective activity can be recorded in the OFC. Finally, the interaction between the OFC and hippocampus illustrates OFC's role in response selection. The OFC may facilitate reward-guided memory retrieval by selecting the memories most relevant to achieve a goal. This model for OFC function places it within the hierarchy of increasingly complex action representations that support decision making.
眶额皮层(OFC)的功能通常以刺激-奖励映射来描述;然而,最近的证据表明,OFC 可能在选择和表示扩展动作中发挥作用。首先,OFC 中先前编码的奖励关联可以用来为新但类似的情况提供响应信息。其次,当在要求动物执行扩展动作的任务中进行评估时,OFC 中可以记录到对响应的选择性活动。最后,OFC 与海马体的相互作用说明了 OFC 在响应选择中的作用。OFC 通过选择最有助于实现目标的记忆来促进奖励导向的记忆检索。OFC 功能的这种模型将其置于支持决策的越来越复杂的动作表示的层次结构内。