Kang Ki-Mun, Kang Young-Nam, Choi Ihil-Bong, Gu Yeunhwa, Kawamura Tomohiro, Toyoda Yoshiya, Nakao Atsunori
Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Med Gas Res. 2011 Jun 7;1(1):11. doi: 10.1186/2045-9912-1-11.
Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy.
A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancer's QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed.
The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups.
Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.
接受放疗的癌症患者常经历疲劳且生活质量受损。放疗的许多副作用被认为与放疗期间活性氧的产生导致氧化应激增加和炎症有关。氢气可作为治疗性医用气体给药，具有抗氧化特性，并可减轻组织炎症。本研究探讨了以富氢水形式进行的氢气治疗是否能改善接受放疗患者的生活质量。
进行了一项随机、安慰剂对照研究，以评估饮用富氢水对49例接受恶性肝肿瘤放疗患者的影响。通过将金属镁棒放入饮用水中制备富氢水（最终氢气浓度为0.55~0.65 mM）。使用欧洲癌症研究与治疗组织的QLQ-C30量表韩文版评估总体健康状况和生活质量。评估外周血中活性氧化代谢产物衍生物的浓度和生物抗氧化能力。
饮用6周富氢水可降低血液中的活性氧代谢产物，并维持血液氧化电位。与饮用安慰剂水的患者相比，饮用富氢水的患者在放疗期间的生活质量评分显著提高。两组之间放疗的肿瘤反应无差异。
每日饮用富氢水是一种潜在的新型治疗策略，可改善放疗后的生活质量。饮用富氢水可降低对辐射诱导的氧化应激的生物反应，而不影响抗肿瘤效果。
